Title : Effects of dipyridamole and inhaled nitric oxide in pediatric patients with pulmonary hypertension.

Pub. Date : 1998 Nov

PMID : 9817684






2 Functional Relationships(s)
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1 Dipyridamole, a drug with several putative vasodilator mechanisms, is an inhibitor of cGMP-specific phosphodiesterases (PDE5); it therefore has the potential to increase pulmonary vascular cGMP levels, lower pulmonary vascular resistance, augment iNO-induced pulmonary vasodilation, and attenuate excessive pulmonary vasoreactivity. Cyclic GMP phosphodiesterase 5A Homo sapiens
2 Dipyridamole, a drug with several putative vasodilator mechanisms, is an inhibitor of cGMP-specific phosphodiesterases (PDE5); it therefore has the potential to increase pulmonary vascular cGMP levels, lower pulmonary vascular resistance, augment iNO-induced pulmonary vasodilation, and attenuate excessive pulmonary vasoreactivity. Cyclic GMP phosphodiesterase 5A Homo sapiens