Title : Cyclic GMP and cGMP-binding phosphodiesterase are required for interleukin-1-induced nitric oxide synthesis in human articular chondrocytes.

Pub. Date : 1998 Oct 16

PMID : 9765278






2 Functional Relationships(s)
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1 In summary, inhibitors of either GC or PDE5 prevented IL-1 induction of iNOS; IL-1 increased the rates of both cGMP generation and hydrolysis; and exogenous PDE hydrolyzable cGMP analog induced iNOS and NO. Cyclic GMP phosphodiesterase 5A Homo sapiens
2 These results suggest that increased cGMP metabolic flux is sufficient to induce iNOS, and GC and PDE5 activities are required for IL-1 induction of iNOS expression via increases in coupled cGMP synthesis and hydrolysis. Cyclic GMP phosphodiesterase 5A Homo sapiens