Title : Role of PKC and AMPK in hypertonicity-stimulated water reabsorption in rat inner medullary collecting ducts.

Pub. Date : 2019 Feb 1

PMID : 30427219






3 Functional Relationships(s)
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1 When inner medullary tissue was treated with the PKC activator phorbol dibutyrate (PDBu), the AMPK activator metformin, or both, AQP2 phosphorylation at S261 was decreased with PDBu or metformin alone, but there was no additive effect on phosphorylation with PDBu and metformin together. Metformin protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus
2 When inner medullary tissue was treated with the PKC activator phorbol dibutyrate (PDBu), the AMPK activator metformin, or both, AQP2 phosphorylation at S261 was decreased with PDBu or metformin alone, but there was no additive effect on phosphorylation with PDBu and metformin together. Metformin protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus
3 When inner medullary tissue was treated with the PKC activator phorbol dibutyrate (PDBu), the AMPK activator metformin, or both, AQP2 phosphorylation at S261 was decreased with PDBu or metformin alone, but there was no additive effect on phosphorylation with PDBu and metformin together. Metformin protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus