Pub. Date : 2018 Jun 29
PMID : 29958542
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We aim to investigate the potential therapeutic effects of combined therapy of resveratrol and metformin on polycystic ovaries via SIRT1 and AMPK activation. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Rattus norvegicus |
| 2 | Resveratrol and metformin increased SIRT1 and AMPK immunreactivity, respectively, compared to the PCOS group. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Rattus norvegicus |
| 3 | CONCLUSIONS: The results suggest that combined therapy of metformin and resveratrol may improve the weight gain, hormone profile and ovarian follicular cell architecture by inducing antioxidant and antiinflammatory systems via SIRT1 and AMPK activation in PCOS. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Rattus norvegicus |