Title : Metformin pretreatment enhanced learning and memory in cerebral forebrain ischaemia: the role of the AMPK/BDNF/P70SK signalling pathway.

Pub. Date : 2016 Oct

PMID : 26960058






5 Functional Relationships(s)
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1 Metformin pretreatment enhanced learning and memory in cerebral forebrain ischaemia: the role of the AMPK/BDNF/P70SK signalling pathway. Metformin protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus
2 Context Metformin induced AMP-activated protein kinase (AMPK) and protected neurons in cerebral ischaemia. Metformin protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus
3 Context Metformin induced AMP-activated protein kinase (AMPK) and protected neurons in cerebral ischaemia. Metformin protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus
4 Conclusion Short-term memory in ischaemic rats treated with metformin increased step-through latency; sensory-motor evaluation was applied and a group of ischaemia rats that were pretreated with metformin showed high levels of BDNF, P70S6K that seemed to be due to increasing AMPK. Metformin protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus
5 Conclusion Short-term memory in ischaemic rats treated with metformin increased step-through latency; sensory-motor evaluation was applied and a group of ischaemia rats that were pretreated with metformin showed high levels of BDNF, P70S6K that seemed to be due to increasing AMPK. Metformin protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus