Title : Metformin, resveratrol, and exendin-4 inhibit high phosphate-induced vascular calcification via AMPK-RANKL signaling.

Pub. Date : 2020 Sep 17

PMID : 32800550






4 Functional Relationships(s)
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1 Metformin, resveratrol, and exendin-4 inhibit high phosphate-induced vascular calcification via AMPK-RANKL signaling. Metformin protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus
2 Inhibition of AMPK by siRNA adversely affected the anti-calcification effects of metformin, resveratrol, and exendin-4 and reversed the reduction of the expression of Rankl by metformin and exendin-4 in the Pi-treated VSMCs. Metformin protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus
3 Inhibition of AMPK by siRNA adversely affected the anti-calcification effects of metformin, resveratrol, and exendin-4 and reversed the reduction of the expression of Rankl by metformin and exendin-4 in the Pi-treated VSMCs. Metformin protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus
4 These data suggest that metformin, resveratrol, and exendin-4 ameliorate Pi-induced vascular calcification by inhibiting osteoblast differentiation of VSMCs, which is mediated by AMPK. Metformin protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus