Metformin

protein kinase AMP-activated catalytic subunit alpha 2 ; Rattus norvegicus







160 Article(s)
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101 25617357 The beneficial effects of AMP kinase activation against oxidative stress are associated with prevention of PPARα-cyclophilin D interaction in cardiomyocytes. 2015 Apr 1 3
102 25634597 Antihyperglycemic mechanism of metformin occurs via the AMPK/LXRα/POMC pathway. 2015 Jan 30 5
103 25849133 Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats. 2015 May 7
104 25936719 Metformin improves anxiety-like behaviors through AMPK-dependent regulation of autophagy following transient forebrain ischemia. 2015 Oct 4
105 26054810 Metformin attenuates hyperalgesia and allodynia in rats with painful diabetic neuropathy induced by streptozotocin. 2015 Oct 5 3
106 26435693 AICAR and Metformin Exert AMPK-dependent Effects on INS-1E Pancreatic β-cell Apoptosis via Differential Downstream Mechanisms. 2015 3
107 24435937 Activation of AMP-activated protein kinase by metformin protects against global cerebral ischemia in male rats: interference of AMPK/PGC-1α pathway. 2014 Mar 8
108 24444314 Crosstalk between AMPK activation and angiotensin II-induced hypertrophy in cardiomyocytes: the role of mitochondria. 2014 Apr 4
109 24611741 Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy. 2014 Jul 6
110 24791887 Metformin inhibits nuclear factor-κB activation and inflammatory cytokines expression induced by high glucose via adenosine monophosphate-activated protein kinase activation in rat glomerular mesangial cells in vitro. 2014 4
111 25108154 Pharmacological activation of AMPK ameliorates perivascular adipose/endothelial dysfunction in a manner interdependent on AMPK and SIRT1. 2014 Nov 1
112 25179145 Metformin exaggerates phenylephrine-induced AMPK phosphorylation independent of CaMKKβ and attenuates contractile response in endothelium-denuded rat aorta. 2014 Nov 15 6
113 25462874 Lipopolysaccharide-induced loss of cultured rat myenteric neurons - role of AMP-activated protein kinase. 2014 1
114 25550773 Hypoxic preconditioning protects cardiomyocytes against hypoxia/reoxygenation injury through AMPK/eNOS/PGC-1α signaling pathway. 2014 1
115 22835064 The antidiabetic drug metformin inhibits uterine leiomyoma cell proliferation via an AMP-activated protein kinase signaling pathway. 2013 Jan 4
116 23223177 Dissociation of Bcl-2-Beclin1 complex by activated AMPK enhances cardiac autophagy and protects against cardiomyocyte apoptosis in diabetes. 2013 Apr 1
117 23523792 Metformin induces up-regulation of blood-brain barrier functions by activating AMP-activated protein kinase in rat brain microvascular endothelial cells. 2013 Apr 19 4
118 23620435 Isoproterenol instigates cardiomyocyte apoptosis and heart failure via AMPK inactivation-mediated endoplasmic reticulum stress. 2013 Jul 1
119 24097562 Metformin-stimulated AMPK-α1 promotes microvascular repair in acute lung injury. 2013 Dec 1
120 24288442 Metformin inhibits expression and secretion of PEDF in adipocyte and hepatocyte via promoting AMPK phosphorylation. 2013 4
121 21964537 Microarray expression analysis in delayed cardioprotection: the effect of exercise, AICAR, or metformin and the possible role of AMP-activated protein kinase (AMPK). 2012 Jan 1
122 22124463 Sirtuin 1-mediated cellular metabolic memory of high glucose via the LKB1/AMPK/ROS pathway and therapeutic effects of metformin. 2012 Jan 1
123 22525678 Metformin-induced AMP-activated protein kinase activation regulates phenylephrine-mediated contraction of rat aorta. 2012 May 11 4
124 23108012 Activation of AMP-activated protein kinase inhibits albumin-induced endoplasmic reticulum stress and apoptosis through inhibition of reactive oxygen species. 2012 2
125 23122726 Short-term treatment with metformin suppresses toll like receptors (TLRs) activity in isoproterenol-induced myocardial infarction in rat: are AMPK and TLRs connected? 2012 Dec 5
126 20189584 Involvement of adenosine monophosphate-activated protein kinase in morphine-induced cardioprotection. 2011 Aug 1
127 21143620 Metformin improves cardiac function in rats via activation of AMP-activated protein kinase. 2011 Feb 3
128 21209024 Phosphorylation and activation of AMP-activated protein kinase (AMPK) by metformin in the human ovary requires insulin. 2011 Mar 1
129 21647332 Mechanism of AMPK suppression of LXR-dependent Srebp-1c transcription. 2011 1
130 21700905 Activated AMPK inhibits PPAR-{alpha} and PPAR-{gamma} transcriptional activity in hepatoma cells. 2011 Oct 1
131 21936900 Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain. 2011 Sep 21 2
132 21947382 Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status. 2011 Dec 1
133 22068032 Role of activation of 5'-adenosine monophosphate-activated protein kinase in gastric ulcer healing in diabetic rats. 2011 8
134 20012266 Metformin increases phagocytosis and acidifies lysosomal/endosomal compartments in AMPK-dependent manner in rat primary microglia. 2010 Feb 5
135 20229055 Transitory activation of AMPK at reperfusion protects the ischaemic-reperfused rat myocardium against infarction. 2010 Feb 2
136 20399918 AMP-activated protein kinase (AMPK) activation regulates in vitro bone formation and bone mass. 2010 Aug 3
137 20583965 Influence of metformin on GLUT1 gene and protein expression in rat streptozotocin diabetes mellitus model. 2010 Jul 3
138 20686344 5-aminoimidazole-4-carboxamide-1-beta-ribofuranoside (AICAR) prevents nuclear translocation of constitutive androstane receptor by AMP-activated protein kinase (AMPK) independent manner. 2010 Aug 1
139 20688914 AMPK-dependent repression of hepatic gluconeogenesis via disruption of CREB.CRTC2 complex by orphan nuclear receptor small heterodimer partner. 2010 Oct 15 3
140 20798864 Metformin Improves Insulin Signaling in Obese Rats via Reduced IKKbeta Action in a Fiber-Type Specific Manner. 2010 1
141 20861072 AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells. 2010 Dec 1
142 21098866 Metformin has adenosine-monophosphate activated protein kinase (AMPK)-independent effects on LPS-stimulated rat primary microglial cultures. 2010 Sep-Oct 8
143 19125418 AMP-activated protein kinase suppresses LXR-dependent sterol regulatory element-binding protein-1c transcription in rat hepatoma McA-RH7777 cells. 2009 Feb 15 5
144 19664596 Metformin suppresses glucose-6-phosphatase expression by a complex I inhibition and AMPK activation-independent mechanism. 2009 Oct 16 4
145 19665995 Curcumin activates AMPK and suppresses gluconeogenic gene expression in hepatoma cells. 2009 Oct 16 2
146 19672815 Glucose, metformin, and AICAR regulate the expression of G protein-coupled receptor members in INS-1 beta cell. 2009 Nov 1
147 18077446 AICAR induces astroglial differentiation of neural stem cells via activating the JAK/STAT3 pathway independently of AMP-activated protein kinase. 2008 Mar 7 2
148 18375721 Metabolic actions of metformin in the heart can occur by AMPK-independent mechanisms. 2008 Jun 5
149 18484962 Metformin induces cardioprotection against ischaemia/reperfusion injury in the rat heart 24 hours after administration. 2008 Jul 7
150 18815214 Mechanisms of myocyte cytotoxicity induced by the multiple receptor tyrosine kinase inhibitor sunitinib. 2008 Dec 1