| 1 |
34862975 | Atorvastatin protects against liver and vascular damage in a model of diet induced steatohepatitis by resetting FXR and GPBAR1 signaling. | 2022 Jan |
1 |
| 2 |
35204252 | NRF2 Activation in Autophagy Defects Suppresses a Pharmacological Transactivation of the Nuclear Receptor FXR. | 2022 Feb 12 |
1 |
| 3 |
35267068 | Farnesoid X receptor (FXR) agonists induce hepatocellular apoptosis and impair hepatic functions via FXR/SHP pathway. | 2022 Jun |
3 |
| 4 |
35439472 | Obeticholic acid orchestrates the crosstalk between ileal autophagy and tight junctions in non-alcoholic steatohepatitis: Role of TLR4/TGF-β1 axis. | 2022 Jul 1 |
1 |
| 5 |
35447541 | Obeticholic acid inhibits hepatic fatty acid uptake independent of FXR in mouse. | 2022 Jun |
3 |
| 6 |
35614939 | Obeticholic Acid Induces Hepatoxicity Via FXR in the NAFLD Mice. | 2022 |
8 |
| 7 |
32811993 | Obeticholic acid ameliorates severity of Clostridioides difficile infection in high fat diet-induced obese mice. | 2021 Mar |
1 |
| 8 |
33049605 | Structure-guided modification of isoxazole-type FXR agonists: Identification of a potent and orally bioavailable FXR modulator. | 2021 Jan 1 |
1 |
| 9 |
33154041 | Regulation of Intestinal UDP-Glucuronosyltransferase 1A1 by the Farnesoid X Receptor Agonist Obeticholic Acid Is Controlled by Constitutive Androstane Receptor through Intestinal Maturation. | 2021 Jan |
3 |
| 10 |
33328206 | Defective FXR-SHP Regulation in Obesity Aberrantly Increases miR-802 Expression, Promoting Insulin Resistance and Fatty Liver. | 2021 Mar |
1 |
| 11 |
33568795 | The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer. | 2021 May |
1 |
| 12 |
33704005 | FXR activation prevents liver injury induced by Tripterygium wilfordii preparations. | 2021 Jun |
3 |
| 13 |
33784797 | Isotschimgine alleviates nonalcoholic steatohepatitis and fibrosis via FXR agonism in mice. | 2021 Jun |
2 |
| 14 |
34045606 | Potential of therapeutic bile acids in the treatment of neonatal Hyperbilirubinemia. | 2021 May 27 |
1 |
| 15 |
34149876 | Co-administration of obeticholic acid and simvastatin protects against high-fat diet-induced non-alcoholic steatohepatitis in mice. | 2021 Aug |
4 |
| 16 |
34410012 | Disordered farnesoid X receptor signaling is associated with liver carcinogenesis in Abcb11-deficient mice. | 2021 Dec |
1 |
| 17 |
34774795 | miR-199a-5p inhibits the expression of ABCB11 in obstructive cholestasis. | 2021 Dec |
2 |
| 18 |
31883408 | Farnesoid X receptor activation induces the degradation of hepatotoxic 1-deoxysphingolipids in non-alcoholic fatty liver disease. | 2020 Apr |
7 |
| 19 |
32098797 | Obeticholic Acid Ameliorates Valproic Acid-Induced Hepatic Steatosis and Oxidative Stress. | 2020 May |
2 |
| 20 |
32170842 | FXR activation promotes intestinal cholesterol excretion and attenuates hyperlipidemia in SR-B1-deficient mice fed a high-fat and high-cholesterol diet. | 2020 Mar |
4 |
| 21 |
32248018 | The protective effect of obeticholic acid on lipopolysaccharide-induced disorder of maternal bile acid metabolism in pregnant mice. | 2020 Jun |
1 |
| 22 |
32436768 | Bile acids, lipid and purine metabolism involved in hepatotoxicity of first-line anti-tuberculosis drugs. | 2020 Jun |
1 |
| 23 |
32505574 | 3β-Isoobeticholic acid efficiently activates the farnesoid X receptor (FXR) due to its epimerization to 3α-epimer by hepatic metabolism. | 2020 Sep |
2 |
| 24 |
32712104 | FXR Isoforms Control Different Metabolic Functions in Liver Cells via Binding to Specific DNA Motifs. | 2020 Nov |
2 |
| 25 |
33304784 | Precise delivery of obeticholic acid via nanoapproach for triggering natural killer T cell-mediated liver cancer immunotherapy. | 2020 Nov |
4 |
| 26 |
30468885 | Obeticholic acid alleviate lipopolysaccharide-induced acute lung injury via its anti-inflammatory effects in mice. | 2019 Jan |
1 |
| 27 |
30580099 | Identification of a novel function of hepatic long-chain acyl-CoA synthetase-1 (ACSL1) in bile acid synthesis and its regulation by bile acid-activated farnesoid X receptor. | 2019 Mar |
3 |
| 28 |
30772394 | Obeticholic acid differentially regulates hepatic injury and inflammation at different stages of D-galactosamine/lipopolysaccharide-evoked acute liver failure. | 2019 May 5 |
2 |
| 29 |
31085240 | Obeticholic acid protects against diabetic cardiomyopathy by activation of FXR/Nrf2 signaling in db/db mice. | 2019 Sep 5 |
2 |
| 30 |
31227742 | Combined obeticholic acid and elafibranor treatment promotes additive liver histological improvements in a diet-induced ob/ob mouse model of biopsy-confirmed NASH. | 2019 Jun 21 |
4 |
| 31 |
31308634 | The protective effect and mechanism of the FXR agonist obeticholic acid via targeting gut microbiota in non-alcoholic fatty liver disease. | 2019 |
1 |
| 32 |
31671330 | Obeticholic acid prevents carbon tetrachloride-induced liver fibrosis through interaction between farnesoid X receptor and Smad3. | 2019 Dec |
2 |
| 33 |
29530598 | Disruption of TFGβ-SMAD3 pathway by the nuclear receptor SHP mediates the antifibrotic activities of BAR704, a novel highly selective FXR ligand. | 2018 May |
2 |
| 34 |
29559521 | FXR activation by obeticholic acid or nonsteroidal agonists induces a human-like lipoprotein cholesterol change in mice with humanized chimeric liver. | 2018 Jun |
4 |
| 35 |
29660435 | Yangonin protects against cholestasis and hepatotoxity via activation of farnesoid X receptor in vivo and in vitro. | 2018 Jun 1 |
2 |
| 36 |
29743187 | Effects of Farnesoid X Receptor Activation on Arachidonic Acid Metabolism, NF-kB Signaling, and Hepatic Inflammation. | 2018 Aug |
2 |
| 37 |
29802399 | Obeticholic acid protects against hepatocyte death and liver fibrosis in a murine model of nonalcoholic steatohepatitis. | 2018 May 25 |
4 |
| 38 |
30354208 | Farnesoid X Receptor Activation by Obeticholic Acid Elevates Liver Low-Density Lipoprotein Receptor Expression by mRNA Stabilization and Reduces Plasma Low-Density Lipoprotein Cholesterol in Mice. | 2018 Oct |
4 |
| 39 |
27865854 | Obeticholic acid protects against carbon tetrachloride-induced acute liver injury and inflammation. | 2017 Jan 1 |
2 |
| 40 |
28130067 | Farnesoid X Receptor Activation Promotes Hepatic Amino Acid Catabolism and Ammonium Clearance in Mice. | 2017 May |
1 |
| 41 |
28406477 | miR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in mice. | 2017 Apr 13 |
1 |
| 42 |
28852062 | Farnesoid X receptor activation protects the kidney from ischemia-reperfusion damage. | 2017 Aug 29 |
3 |
| 43 |
28987596 | Computational discovery and experimental verification of farnesoid X receptor agonist auraptene to protect against cholestatic liver injury. | 2017 Dec 15 |
2 |
| 44 |
29174575 | Obeticholic acid protects mice against lipopolysaccharide-induced liver injury and inflammation. | 2017 Dec |
2 |
| 45 |
26655953 | Farnesoid X Receptor Protects against Kidney Injury in Uninephrectomized Obese Mice. | 2016 Jan 29 |
1 |
| 46 |
26811456 | Obeticholic acid, a synthetic bile acid agonist of the farnesoid X receptor, attenuates experimental autoimmune encephalomyelitis. | 2016 Feb 9 |
3 |
| 47 |
27359351 | Farnesoid X receptor activation increases reverse cholesterol transport by modulating bile acid composition and cholesterol absorption in mice. | 2016 Oct |
4 |
| 48 |
27475255 | Bile acid receptor agonists INT747 and INT777 decrease oestrogen deficiency-related postmenopausal obesity and hepatic steatosis in mice. | 2016 Nov |
1 |
| 49 |
24475141 | Farnesoid X receptor ligand prevents cisplatin-induced kidney injury by enhancing small heterodimer partner. | 2014 |
3 |
| 50 |
24713361 | The FXR agonist 6ECDCA reduces hepatic steatosis and oxidative stress induced by ethanol and low-protein diet in mice. | 2014 Jun 25 |
3 |