Pub. Date : 2022
PMID : 35614939
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Objective: Obeticholic acid (OCA), a potent farnesoid X receptor (FXR) agonist, is a promising drug for nonalcoholic fatty liver disease (NAFLD); however, it can cause liver injury, especially at high doses. | obeticholic acid | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 2 | Objective: Obeticholic acid (OCA), a potent farnesoid X receptor (FXR) agonist, is a promising drug for nonalcoholic fatty liver disease (NAFLD); however, it can cause liver injury, especially at high doses. | obeticholic acid | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 3 | Objective: Obeticholic acid (OCA), a potent farnesoid X receptor (FXR) agonist, is a promising drug for nonalcoholic fatty liver disease (NAFLD); however, it can cause liver injury, especially at high doses. | obeticholic acid | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 4 | Objective: Obeticholic acid (OCA), a potent farnesoid X receptor (FXR) agonist, is a promising drug for nonalcoholic fatty liver disease (NAFLD); however, it can cause liver injury, especially at high doses. | obeticholic acid | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 5 | Methods: Wild-type (WT) mice and FXR-/- mice were administered with over-dose OCA (0.40%) and high-dose OCA (0.16%), in a high-fat diet. | obeticholic acid | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 6 | High-dose OCA caused hepatic stellate cell activation and liver fibrosis in the presence of FXR. | obeticholic acid | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 7 | Furthermore, high-dose OCA induced cholesterol accumulation in livers via the upregulation of genes involved in cholesterol acquisition and downregulation of genes regulating cholesterol degradation in liver, leading to the production of interleukin -1beta and an FXR-mediated inflammatory response. | obeticholic acid | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 8 | Conclusion: The high-dose OCA induced FXR-dependent hepatic injury via cholesterol accumulation and interleukin -1beta pathway in the NAFLD mice. | obeticholic acid | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |