Title : Regulation of Intestinal UDP-Glucuronosyltransferase 1A1 by the Farnesoid X Receptor Agonist Obeticholic Acid Is Controlled by Constitutive Androstane Receptor through Intestinal Maturation.

Pub. Date : 2021 Jan

PMID : 33154041






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Regulation of intestinal UGT1A1 by the FXR agonist obeticholic acid (OCA) is controlled by CAR through intestinal maturation. obeticholic acid nuclear receptor subfamily 1, group H, member 4 Mus musculus
2 Neonatal humanized UGT1 mice (hUGT1), which accumulate severe levels of total serum bilirubin (TSB), were treated by oral gavage with obeticholic acid (OCA), a potent FXR agonist. obeticholic acid nuclear receptor subfamily 1, group H, member 4 Mus musculus
3 Thus, new findings link an important role for CAR in intestinal UGT1A1 induction and its role in the intestinal maturation pathway Significance Statement Obeticholic acid (OCA) activates FXR target genes in both liver and intestinal tissues while inducing intestinal UGT1A1 which leads to the elimination of serum bilirubin in hUGT1 mice. obeticholic acid nuclear receptor subfamily 1, group H, member 4 Mus musculus