Pub. Date : 2021 Dec
PMID : 34774795
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We also show treatment of mice after CBDL with the potent nuclear receptor FXR agonist obeticholic acid (OCA) significantly increased Abcb11 mRNA and protein and decreased miR-199a-5p expression. | obeticholic acid | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 2 | In conclusion, we demonstrate that miR-199a-5p is involved in regulating ABCB11/Abcb11 expression, is aberrantly upregulated in obstructive cholestasis, and is downregulated by the FXR agonist obeticholic acid. | obeticholic acid | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |