Title : Disruption of TFGβ-SMAD3 pathway by the nuclear receptor SHP mediates the antifibrotic activities of BAR704, a novel highly selective FXR ligand.

Pub. Date : 2018 May

PMID : 29530598






2 Functional Relationships(s)
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1 While targeting FXR holds promise, 6-ethyl-CDCA known as obeticholic acid, the first in class of FXR ligands, causes side effects, partially because the lack of selectivity toward GPBAR1, a putative itching receptor. obeticholic acid nuclear receptor subfamily 1, group H, member 4 Mus musculus
2 While targeting FXR holds promise, 6-ethyl-CDCA known as obeticholic acid, the first in class of FXR ligands, causes side effects, partially because the lack of selectivity toward GPBAR1, a putative itching receptor. obeticholic acid nuclear receptor subfamily 1, group H, member 4 Mus musculus