Tyrosine

cyclin dependent kinase 1 ; Homo sapiens







201 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
1 35056723 Anticancer Effects and Molecular Action of 7-α-Hydroxyfrullanolide in G2/M-Phase Arrest and Apoptosis in Triple Negative Breast Cancer Cells. 2022 Jan 9 1
2 33465289 The tyrosine kinase v-Src modifies cytotoxicities of anticancer drugs targeting cell division. 2021 Feb 2
3 31760882 Aberrant activation of cyclin A-CDK induces G2/M-phase checkpoint in human cells. 2020 Jan 1
4 31914610 The UFM1 cascade times mitosis entry associated with microcephaly. 2020 Jan 2
5 32277442 A comparative molecular analysis of DNA damage response, cell cycle progression, viability and apoptosis of malignant granulosa cells exposed to gemcitabine and cisplatin. 2020 May 1
6 30754676 C/EBPβ Is a Transcriptional Regulator of Wee1 at the G₂/M Phase of the Cell Cycle. 2019 Feb 11 1
7 31200459 Wee1 Rather Than Plk1 Is Inhibited by AZD1775 at Therapeutically Relevant Concentrations. 2019 Jun 13 3
8 31285938 Helicobacter pylori inhibited cell proliferation in human periodontal ligament fibroblasts through the Cdc25C/CDK1/cyclinB1 signaling cascade. 2019 Jun 2
9 29606300 Homozygous Mutations in WEE2 Cause Fertilization Failure and Female Infertility. 2018 Apr 5 1
10 29754473 Actin Dysfunction Induces Cell Cycle Delay at G2/M with Sustained ERK and RSK Activation in IMR-90 Normal Human Fibroblasts. 2018 May 31 1
11 29783721 AZD1775 Increases Sensitivity to Olaparib and Gemcitabine in Cancer Cells with p53 Mutations. 2018 May 19 1
12 30067982 The Tumor Suppressor MIG6 Controls Mitotic Progression and the G2/M DNA Damage Checkpoint by Stabilizing the WEE1 Kinase. 2018 Jul 31 1
13 30135207 The tyrosine kinase v-Src causes mitotic slippage by phosphorylating an inhibitory tyrosine residue of Cdk1. 2018 Oct 5 5
14 29163782 BMI1 reduces ATR activation and signalling caused by hydroxyurea. 2017 Oct 27 1
15 26409447 Resveratrol inhibits oral squamous cell carcinoma through induction of apoptosis and G2/M phase cell cycle arrest. 2016 Mar 1
16 27070276 Reduced O-GlcNAcase expression promotes mitotic errors and spindle defects. 2016 May 18 2
17 27123550 Cytotoxic activity of a synthetic deoxypodophyllotoxin derivative with an opened D-ring. 2016 May 2
18 25204801 The GPER agonist G-1 induces mitotic arrest and apoptosis in human vascular smooth muscle cells independent of GPER. 2015 Apr 1
19 25435947 Anticancer effects of CKD-602 (Camtobell®) via G2/M phase arrest in oral squamous cell carcinoma cell lines. 2015 Jan 1
20 25732194 Dependency of 2-methoxyestradiol-induced mitochondrial apoptosis on mitotic spindle network impairment and prometaphase arrest in human Jurkat T cells. 2015 Apr 15 1
21 25872745 Hepatitis B virus X protein activates the ATM-Chk2 pathway and delays cell cycle progression. 2015 Aug 1
22 25994054 Morphological, cellular and molecular changes during postovulatory egg aging in mammals. 2015 May 22 2
23 26131711 Two Distinct Cdc2 Pools Regulate Cell Cycle Progression and the DNA Damage Response in the Fission Yeast S.pombe. 2015 1
24 26216057 DNA damage control: regulation and functions of checkpoint kinase 1. 2015 Oct 1
25 24798733 Chk2 prevents mitotic exit when the majority of kinetochores are unattached. 2014 May 12 1
26 24872417 Phosphorylation of cyclin-dependent kinase 5 (Cdk5) at Tyr-15 is inhibited by Cdk5 activators and does not contribute to the activation of Cdk5. 2014 Jul 11 1
27 25084614 CHK1 plays a critical role in the anti-leukemic activity of the wee1 inhibitor MK-1775 in acute myeloid leukemia cells. 2014 Aug 1 1
28 23397083 Sensitization of lung cancer cells to cisplatin by β-elemene is mediated through blockade of cell cycle progression: antitumor efficacies of β-elemene and its synthetic analogs. 2013 Mar 2
29 23671119 Essential role for Cdk2 inhibitory phosphorylation during replication stress revealed by a human Cdk2 knockin mutation. 2013 May 28 1
30 22012316 Reactive-oxygen-species-mediated Cdc25C degradation results in differential antiproliferative activities of vanadate, tungstate, and molybdate in the PC-3 human prostate cancer cell line. 2012 Feb 1
31 22084170 MK1775, a selective Wee1 inhibitor, shows single-agent antitumor activity against sarcoma cells. 2012 Jan 1
32 22580740 Pirarubicin inhibits multidrug-resistant osteosarcoma cell proliferation through induction of G2/M phase cell cycle arrest. 2012 Jun 1
33 20840867 ERK1 and ERK2 kinases activate hydroxyurea-induced S-phase checkpoint in MCF7 cells by mediating ATR activation. 2011 Jan 1
34 21321122 Human papillomavirus (HPV) E7 induces prolonged G2 following S phase reentry in differentiated human keratinocytes. 2011 Apr 29 1
35 21734451 Wip1 contributes to cell homeostasis maintained by the steady-state level of Wtp53. 2011 Aug 1 4
36 21900237 CDK1-mediated phosphorylation of Abi1 attenuates Bcr-Abl-induced F-actin assembly and tyrosine phosphorylation of WAVE complex during mitosis. 2011 Nov 4 1
37 22204398 The cannabinoid receptors agonist WIN55212-2 inhibits macrophageal differentiation and alters expression and phosphorylation of cell cycle control proteins. 2011 Dec 28 1
38 19795419 Restoration of absent in melanoma 2 (AIM2) induces G2/M cell cycle arrest and promotes invasion of colorectal cancer cells. 2010 Apr 15 1
39 19858290 A bifunctional regulatory element in human somatic Wee1 mediates cyclin A/Cdk2 binding and Crm1-dependent nuclear export. 2010 Jan 1
40 19917613 The protein kinase Cdelta catalytic fragment is critical for maintenance of the G2/M DNA damage checkpoint. 2010 Jan 15 1
41 20360007 Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition. 2010 May 28 3
42 20368335 Pro-apoptotic role of Cdc25A: activation of cyclin B1/Cdc2 by the Cdc25A C-terminal domain. 2010 Jun 4 2
43 20395957 New Cdc2 Tyr 4 phosphorylation by dsRNA-activated protein kinase triggers Cdc2 polyubiquitination and G2 arrest under genotoxic stresses. 2010 May 15
44 20406171 Abrogation of the G2 checkpoint by inhibition of Wee-1 kinase results in sensitization of p53-deficient tumor cells to DNA-damaging agents. 2010 Aug 1
45 20926293 Chalcone HTMC causes in vitro selective cytotoxicity, cell-cycle G1 phase arrest through p53-dependent pathway in human lung adenocarcinoma A549 cells, and in vivo tumor growth suppression. 2010 Nov 15 1
46 22993588 G2/M accumulation in prostate cancer cell line PC-3 is induced by Cdc25 inhibitor 7-chloro-6-(2-morpholin-4-ylethylamino) quinoline-5, 8-dione (DA 3003-2). 2010 Jul 1
47 19527713 Bleomycin-induced over-replication involves sustained inhibition of mitotic entry through the ATM/ATR pathway. 2009 Sep 10 1
48 19530246 Involvement of ATM-mediated Chk1/2 and JNK kinase signaling activation in HKH40A-induced cell growth inhibition. 2009 Oct 2
49 19730430 LGH00031, a novel ortho-quinonoid inhibitor of cell division cycle 25B, inhibits human cancer cells via ROS generation. 2009 Sep 3
50 17869387 Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases. 2008 Jun 2