Title : LGH00031, a novel ortho-quinonoid inhibitor of cell division cycle 25B, inhibits human cancer cells via ROS generation.

Pub. Date : 2009 Sep

PMID : 19730430






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 LGH00031 increased cyclin-dependent kinase 1 (CDK1) tyrosine 15 phosphorylation and cyclin B1 protein level. Tyrosine cyclin dependent kinase 1 Homo sapiens
2 LGH00031 increased cyclin-dependent kinase 1 (CDK1) tyrosine 15 phosphorylation and cyclin B1 protein level. Tyrosine cyclin dependent kinase 1 Homo sapiens
3 Correspondingly, the LGH00031-induced decrease in cell viability and cell cycle arrest, cyclin B1 protein level, and phosphorylation of CDK1 tyrosine 15 were also rescued by NAC that decreased ROS production. Tyrosine cyclin dependent kinase 1 Homo sapiens