Title : CHK1 plays a critical role in the anti-leukemic activity of the wee1 inhibitor MK-1775 in acute myeloid leukemia cells.

Pub. Date : 2014 Aug 1

PMID : 25084614






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 MK-1775 induced apoptosis in both AML cell lines and diagnostic blast samples, accompanied by decreased phosphorylation of CDK1 and CDK2 on Tyr-15 and increased DNA double-strand breaks (DSBs). Tyrosine cyclin dependent kinase 1 Homo sapiens