Title : Chalcone HTMC causes in vitro selective cytotoxicity, cell-cycle G1 phase arrest through p53-dependent pathway in human lung adenocarcinoma A549 cells, and in vivo tumor growth suppression.

Pub. Date : 2010 Nov 15

PMID : 20926293






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 HTMC treatment also led to an inhibition of cell-cycle regulatory proteins phosphorylation of cdc2 (Tyr(15) and Tyr(161)) and Rb (Ser(795) and Ser(807/811)), which was accompanied by the accumulation of tumor suppressor genes p53 and p21. Tyrosine cyclin dependent kinase 1 Homo sapiens