Oligonucleotides

coagulation factor II, thrombin ; Homo sapiens







81 Article(s)
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1 33298665 Activated Factor XI is Increased in Plasma in Response to Surgical Trauma but not to Recombinant Activated FVII-Induced Thrombin Formation. 2022 Jan 1 1
2 34985829 Improving Structural Stability and Anticoagulant Activity of a Thrombin Binding Aptamer by Aromatic Modifications. 2022 Mar 18 1
3 32202471 Molecular dynamics simulations of human α-thrombin in different structural contexts: evidence for an aptamer-guided cooperation between the two exosites. 2021 Apr 1
4 32777331 G-quadruplex-based aptamers targeting human thrombin: Discovery, chemical modifications and antithrombotic effects. 2021 Jan 2
5 33672736 Functional Characterization of Antithrombin Mutations by Monitoring of Thrombin Inhibition Kinetics. 2021 Feb 20 1
6 34270267 Construction of Aptamer-Based Molecular Beacons with Varied Blocked Structures and Targeted Detection of Thrombin. 2021 Jul 27 1
7 34361773 Structural and Binding Effects of Chemical Modifications on Thrombin Binding Aptamer (TBA). 2021 Jul 30 1
8 32485818 Design, Synthesis and Characterization of Cyclic NU172 Analogues: A Biophysical and Biological Insight. 2020 May 29 1
9 33142935 Label-Free Oligonucleotide-Based SPR Biosensor for the Detection of the Gene Mutation Causing Prothrombin-Related Thrombophilia. 2020 Oct 31 3
10 29893124 Electroactivity of Aptamer at Soft Microinterface Arrays. 2018 Jul 17 1
11 27094310 A new measure for in vivo thrombin activity in comparison with in vitro thrombin generation potential in patients with hyper- and hypocoagulability. 2017 May 1
12 28938065 In Vitro Selection of Diversely Functionalized Aptamers. 2017 Oct 11 1
13 27108282 An aptamer assay using rolling circle amplification coupled with thrombin catalysis for protein detection. 2016 Jul 1
14 27183984 G-Quadruplex Aptamers to Human Thrombin Versus Other Direct Thrombin Inhibitors: The Focus on Mechanism of Action and Drug Efficiency as Anticoagulants. 2016 1
15 27877881 Crosslinked duplex DNA nanogels that target specified proteins. 2016 1
16 25908518 Using gold aggregation to probe the inhibition and destruction of the G-quadruplex structure by TT-dimerization. 2015 Jun 1 1
17 25069814 Short-term venous stasis induces fibrinolytic activation but not thrombin formation. 2014 1
18 25121606 Impact of hormone-associated resistance to activated protein C on the thrombotic potential of oral contraceptives: a prospective observational study. 2014 1
19 25296283 A straightforward modification in the thrombin binding aptamer improving the stability, affinity to thrombin and nuclease resistance. 2014 Nov 28 1
20 22917918 A label-free electrochemiluminescence aptasensor for thrombin based on novel assembly strategy of oligonucleotide and luminol functionalized gold nanoparticles. 2013 Jan 15 2
21 23102434 Selective and sensitive turn-on detection of adenosine triphosphate and thrombin based on bifunctional fluorescent oligonucleotide probe. 2013 Mar 15 1
22 23665577 An electrochemiluminescence aptasensor for thrombin using graphene oxide to immobilize the aptamer and the intercalated [Formula: see text] probe. 2013 Oct 15 1
23 23770393 A new method for the detection of adenosine based on time-resolved fluorescence sensor. 2013 Nov 15 1
24 24128303 Dissecting the contribution of thrombin exosite I in the recognition of thrombin binding aptamer. 2013 Dec 1
25 22274722 Thrombin inhibition profiles in healthy individuals and thrombophilic patients. 2012 May 1
26 22452720 Quantitation of femtomolar protein levels via direct readout with the electrochemical proximity assay. 2012 Apr 25 1
27 26605637 Free-Energy Landscape of a Thrombin-Binding DNA Aptamer in Aqueous Environment. 2012 Nov 13 1
28 21511000 Loop residues of thrombin-binding DNA aptamer impact G-quadruplex stability and thrombin binding. 2011 Aug 1
29 21922082 Combination of π-π stacking and electrostatic repulsion between carboxylic carbon nanoparticles and fluorescent oligonucleotides for rapid and sensitive detection of thrombin. 2011 Oct 28 1
30 22156241 Fluorescence detection of potassium ion using the G-quadruplex structure. 2011 1
31 20152425 An aptamer-based assay for thrombin via structure switch based on gold nanoparticles and magnetic nanoparticles. 2010 Mar 15 5
32 20695220 [Comparative thermodynamic analysis of thrombin interaction with anti-thrombin aptamers and their heterodimeric construct]. 2010 May-Jun 1
33 20799837 Direct detection of aptamer-thrombin binding via surface-enhanced Raman spectroscopy. 2010 Jul-Aug 1
34 21240367 Anticoagulant effects of thioanalogs of thrombin-binding DNA-aptamer and their stability in the plasma. 2010 Dec 1
35 19243167 Combinatorial synthesis of thrombin-binding aptamers containing iso-guanine. 2009 May-Jun 1
36 19431189 Kinetic optimization of a protein-responsive aptamer beacon. 2009 Aug 15 2
37 19865704 Cation localization and movement within DNA thrombin binding aptamer in solution. 2009 Nov 21 1
38 19902090 Inhibition of thrombin activity with DNA-aptamers. 2009 Jul 1
39 17973086 Label-free homogeneous detection of immunoglobulin E by an aptameric enzyme subunit. 2008 Mar 1
40 18318508 Method of measuring oligonucleotide-metal affinities: interactions of the thrombin binding aptamer with K+ and Sr2+. 2008 Apr 1 1
41 18665927 4-thio-deoxyuridylate-modified thrombin aptamer and its inhibitory effect on fibrin clot formation, platelet aggregation and thrombus growth on subendothelial matrix. 2008 Oct 2
42 18709204 Aptamer-based electrochemical sensors that are not based on the target binding-induced conformational change of aptamers. 2008 Sep 7
43 19367849 Aptamer-based SERRS sensor for thrombin detection. 2008 Dec 2
44 17596136 Neuron-derived orphan receptor-1 (NOR-1) is induced by thrombin and mediates vascular endothelial cell growth. 2007 Aug 1
45 17693958 Synthesis of functionalised nucleosides for incorporation into nucleic acid-based serine protease mimics. 2007 Jan 31 1
46 18029605 Aptameric enzyme subunit for homogeneous protein sensing. 2007 1
47 16414289 A cellular model system for expression studies of coagulation proteins. 2006 Jul-Aug 3
48 15447940 Distinct PKC isoforms mediate cell survival and DNA synthesis in thrombin-induced myofibroblasts. 2005 Jan 1
49 16201905 A potent inhibitor of prothrombin gene expression as a result of standardized target site selection and design of antisense oligonucleotides. 2005 Fall 1
50 16366535 A reagentless signal-on architecture for electronic, aptamer-based sensors via target-induced strand displacement. 2005 Dec 28 1