Title : Distinct PKC isoforms mediate cell survival and DNA synthesis in thrombin-induced myofibroblasts.

Pub. Date : 2005 Jan

PMID : 15447940






1 Functional Relationships(s)
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1 Inhibition of PKC by calphostin or PKC-alpha, but not PKC-epsilon, by antisense oligonucleotides prevents thrombin-induced MAPK phosphorylation and accumulation of G(1) phase regulatory protein cyclin D1, suggesting that PKC-alpha, MAPK, and cyclin D1 mediate lung fibroblast proliferation. Oligonucleotides coagulation factor II, thrombin Homo sapiens