Title : Kinetic optimization of a protein-responsive aptamer beacon.

Pub. Date : 2009 Aug 15

PMID : 19431189






2 Functional Relationships(s)
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1 For example, rational design methods have been utilized to adapt anti-thrombin aptamers to function as biosensors by hybridizing an antisense oligonucleotide containing a quencher to the aptamer containing a fluorescent label. Oligonucleotides coagulation factor II, thrombin Homo sapiens
2 In the presence of thrombin, the binding equilibrium is shifted, the antisense oligonucleotide dissociates, and the beacon lights up. Oligonucleotides coagulation factor II, thrombin Homo sapiens