Quinazolines

epidermal growth factor receptor ; Homo sapiens







134 Article(s)
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51 26681186 Quinazolines as Apoptosis Inducers and Inhibitors: A Review of Patent Literature. 2016 2
52 26763193 Synthesis of p-O-Alkyl Salicylanilide Derivatives as Novel EGFR Inhibitors. 2016 Feb 1
53 26829280 Novel 4-anilinoquinazoline derivatives featuring an 1-adamantyl moiety as potent EGFR inhibitors with enhanced activity against NSCLC cell lines. 2016 Mar 3 2
54 26879314 Novel morpholin-3-one fused quinazoline derivatives as EGFR tyrosine kinase inhibitors. 2016 Mar 15 2
55 27102572 EGFR inhibitors identified as a potential treatment for chordoma in a focused compound screen. 2016 Jul 1
56 27118497 Facile and efficient synthesis and biological evaluation of 4-anilinoquinazoline derivatives as EGFR inhibitors. 2016 Jun 1 1
57 27132165 Design, synthesis, anti-tumor activity, and molecular modeling of quinazoline and pyrido[2,3-d]pyrimidine derivatives targeting epidermal growth factor receptor. 2016 Aug 8 2
58 27135370 Combined inhibition of the EGFR/AKT pathways by a novel conjugate of quinazoline with isothiocyanate. 2016 Jul 19 1
59 27209475 In silico evaluation, molecular docking and QSAR analysis of quinazoline-based EGFR-T790M inhibitors. 2016 Aug 2
60 27387355 6-Oxooxazolidine-quinazolines as noncovalent inhibitors with the potential to target mutant forms of EGFR. 2016 Aug 15 2
61 27491023 Tyrosine Kinase Inhibitors. 20. Optimization of Substituted Quinazoline and Pyrido[3,4-d]pyrimidine Derivatives as Orally Active, Irreversible Inhibitors of the Epidermal Growth Factor Receptor Family. 2016 Sep 8 2
62 25092264 Positional isomerization of a non-cleavable combi-molecule dramatically altered tumor cell response profile. 2015 Feb 2
63 25462282 Design, synthesis and biological evaluation of 6-(nitroimidazole-1H-alkyloxyl)-4-anilinoquinazolines as efficient EGFR inhibitors exerting cytotoxic effects both under normoxia and hypoxia. 2015 Jan 7 1
64 25910402 Quinazoline derivatives as anticancer drugs: a patent review (2011 - present). 2015 Jul 2
65 25948633 EGFR Mutations and Resistance to Irreversible Pyrimidine-Based EGFR Inhibitors. 2015 Sep 1 2
66 26238612 Novel quinazoline derivatives exhibit antitumor activity by inhibiting JAK2/STAT3. 2015 Oct 2
67 26310890 Structure-activity study of quinazoline derivatives leading to the discovery of potent EGFR-T790M inhibitors. 2015 Sep 18 1
68 24269963 The ErbB/HER family of protein-tyrosine kinases and cancer. 2014 Jan 1
69 24387079 Epidermal growth factor receptor inhibitors: a patent review (2010 - present). 2014 Mar 1
70 24928736 ErbB/HER protein-tyrosine kinases: Structures and small molecule inhibitors. 2014 Sep 1
71 24953979 Novel therapeutic strategies for patients with NSCLC that do not respond to treatment with EGFR inhibitors. 2014 Sep 1
72 24992720 QSAR-based models for designing quinazoline/imidazothiazoles/pyrazolopyrimidines based inhibitors against wild and mutant EGFR. 2014 5
73 25305687 Optimization of gefitinib analogues with potent anticancer activity. 2014 Nov 15 1
74 25409491 A chemical tuned strategy to develop novel irreversible EGFR-TK inhibitors with improved safety and pharmacokinetic profiles. 2014 Dec 11 1
75 23847159 6-Aryl and heterocycle quinazoline derivatives as potent EGFR inhibitors with improved activity toward gefitinib-sensitive and -resistant tumor cell lines. 2013 Sep 1
76 23959266 ZRX1, the first EGFR inhibitor-capecitabine based combi-molecule, requires carboxylesterase-mediated hydrolysis for optimal activity. 2013 Dec 1
77 26417222 Combined 3D-QSAR modeling and molecular docking study on multi-acting quinazoline derivatives as HER2 kinase inhibitors. 2013 2
78 21764376 EGFR exon 20 insertion mutations in non-small-cell lung cancer: preclinical data and clinical implications. 2012 Jan 2
79 22043991 Recent developments of small molecule EGFR inhibitors based on the quinazoline core scaffolds. 2012 May 2
80 22169601 Novel inhibitors of epidermal growth factor receptor: (4-(Arylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)(1H-indol-2-yl)methanones and (1H-indol-2-yl)(4-(phenylamino)thieno[2,3-d]pyrimidin-6-yl)methanones. 2012 Jan 1 1
81 22309911 Synthesis and biological evaluation of quinazoline and quinoline bearing 2,2,6,6-tetramethylpiperidine-N-oxyl as potential epidermal growth factor receptor(EGFR) tyrosine kinase inhibitors and EPR bio-probe agents. 2012 Mar 2
82 22421369 Enhancement of the cytotoxic potential of the mixed EGFR and DNA-targeting 'combi-molecule' ZRBA1 against human solid tumour cells by a bis-quinazoline-based drug design approach. 2012 Jun 5
83 22818848 Novel oxazolo[4,5-g]quinazolin-2(1H)-ones: dual inhibitors of EGFR and Src protein tyrosine kinases. 2012 Sep 1
84 22901387 Discovery of 6-substituted 4-anilinoquinazolines with dioxygenated rings as novel EGFR tyrosine kinase inhibitors. 2012 Sep 15 2
85 22959248 Synthesis and biological evaluation of crown ether fused quinazoline analogues as potent EGFR inhibitors. 2012 Oct 1 1
86 21254978 Novel substituted quinazolines for potent EGFR tyrosine kinase inhibitors. 2011 1
87 21294849 Synthesis and studies on three-compartment flavone-containing combi-molecules designed to target EGFR, DNA, and MEK. 2011 May 1
88 21677478 [Erlotinib in non-small cell lung cancer]. 2011 Jun 1
89 21789172 AST1306, a novel irreversible inhibitor of the epidermal growth factor receptor 1 and 2, exhibits antitumor activity both in vitro and in vivo. 2011 1
90 21811593 Prediction of inhibitory activity of epidermal growth factor receptor inhibitors using grid search-projection pursuit regression method. 2011 2
91 20222923 Refractory aggressive keratoacanthoma centrifugum marginatum of the scalp controlled with the epidermal growth factor receptor inhibitor erlotinib. 2010 Sep 1
92 20599299 Design, synthesis and biological evaluation of novel quinazoline derivatives as potential antitumor agents: molecular docking study. 2010 Sep 1
93 20627376 New substituted 4-arylaminoquinazolines as potent inhibitors of breast tumor cell lines: in vitro and docking experiments. 2010 Sep 1
94 20657425 Receptor-based virtual screening of EGFR kinase inhibitors from the NCI diversity database. 2010 Jun 4 1
95 24825983 3d QSAR studies on a series of quinazoline derrivatives as tyrosine kinase (egfr) inhibitor: the k-nearest neighbor molecular field analysis approach. 2010 Jun 2
96 18771819 Synthesis and in vitro antitumor activities of novel 4-anilinoquinazoline derivatives. 2009 Jul 1
97 19275520 Synthesis of quinazolines as tyrosine kinase inhibitors. 2009 Mar 1
98 19291100 Rational design of multitargeted tyrosine kinase inhibitors: a novel approach. 2009 Apr 1
99 18465761 Allene as an alternative functional group for drug design: effect of C--C multiple bonds conjugated with quinazolines on the inhibition of EGFR tyrosine kinase. 2008 Jul 2
100 18585943 Homology models of the mutated EGFR and their response towards quinazoline analogues. 2008 Oct 1