Quinazolines

epidermal growth factor receptor ; Homo sapiens







134 Article(s)
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101 18608750 QSAR of aromatic substances: EGFR inhibitory activity of quinazoline analogues. 2008 Dec 1
102 18688420 Rhenium and technetium complexes bearing quinazoline derivatives: progress towards a 99mTc biomarker for EGFR-TK imaging. 2008 Jun 28 2
103 18702009 Synthesis and characterization of novel quinazoline type inhibitors for mutant and wild-type EGFR and RICK kinases. 2008 2
104 20477246 Erlotinib: an EGF receptor tyrosine kinase inhibitor in non-small-cell lung cancer treatment. 2008 Apr 1
105 17404024 The epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 (Iressa) suppresses proliferation and invasion of human oral squamous carcinoma cells via p53 independent and MMP, uPAR dependent mechanism. 2007 Jan 1
106 17416531 Dual irreversible kinase inhibitors: quinazoline-based inhibitors incorporating two independent reactive centers with each targeting different cysteine residues in the kinase domains of EGFR and VEGFR-2. 2007 Jun 1 1
107 17449254 Radioiodination of new EGFR inhibitors as potential SPECT agents for molecular imaging of breast cancer. 2007 Jun 15 3
108 17591829 Erlotinib in cancer treatment. 2007 Jun 1
109 16275081 Acryloylamino-salicylanilides as EGFR PTK inhibitors. 2006 Jan 15 1
110 16480284 Tyrosine kinase inhibitors. 19. 6-Alkynamides of 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB family of tyrosine kinase receptors. 2006 Feb 23 1
111 16107496 Gefitinib (ZD1839) combined with weekly epirubicin in patients with metastatic breast cancer: a phase I study with biological correlate. 2005 Dec 1
112 16336752 Overview of monoclonal antibodies and small molecules targeting the epidermal growth factor receptor pathway in colorectal cancer. 2005 Nov 2
113 14991862 Inhibition of cell signaling by the combi-nitrosourea FD137 in the androgen independent DU145 prostate cancer cell line. 2004 Apr 1 2
114 14997040 Evaluation of novel epidermal growth factor receptor tyrosine kinase inhibitors. 2004 Jan 1
115 15345335 Molecular mechanisms of ZD1839-induced G1-cell cycle arrest and apoptosis in human lung adenocarcinoma A549 cells. 2004 Oct 1 1
116 15469331 Synthesis of AX7593, a quinazoline-derived photoaffinity probe for EGFR. 2004 Oct 14 1
117 15475435 Modulation of DNA repair in vitro after treatment with chemotherapeutic agents by the epidermal growth factor receptor inhibitor gefitinib (ZD1839). 2004 Oct 1 1
118 12447985 Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs): simple drugs with a complex mechanism of action? 2003 Jan 2
119 12712332 Prostate cancer cell proliferation is strongly reduced by the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 in vitro on human cell lines and primary cultures. 2003 Mar 2
120 12840799 Erlotinib (Tarceva): an update on the clinical trial program. 2003 Jun 1
121 12859950 Achieving selectivity between highly homologous tyrosine kinases: a novel selective erbB2 inhibitor. 2003 Jul 25 2
122 12923594 Successful treatment of multifocal bronchioloalveolar cell carcinoma with ZD1839 (Iressa) in two patients. 2003 Jun 1
123 15314969 Anti-HER therapeutic agents in the treatment of non-small-cell lung cancer. 2003 1
124 12171571 4-anilino-3-quinolinecarbonitriles: an emerging class of kinase inhibitors. 2002 Sep 1
125 11550209 Effect of an EGF-R selective tyrosine kinase inhibitor and an anti-androgen on LNCaP cells: identification of divergent growth regulatory pathways. 2001 Sep 15 2
126 11585755 The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: potential therapy for cancer. 2001 Oct 1 1
127 12188892 Structure-based design of novel anticancer agents. 2001 May 1
128 10702262 Reversible G(1) arrest induced by inhibition of the epidermal growth factor receptor tyrosine kinase requires up-regulation of p27(KIP1) independent of MAPK activity. 2000 Mar 10 2
129 10753475 Tyrosine kinase inhibitors. 17. Irreversible inhibitors of the epidermal growth factor receptor: 4-(phenylamino)quinazoline- and 4-(phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides bearing additional solubilizing functions. 2000 Apr 6 2
130 10815932 Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor. 2000 May 1
131 11129168 Epidermal growth factor receptor tyrosine kinase as a target for anticancer therapy. 2000 1
132 11129169 Epidermal growth factor receptor tyrosine kinase inhibitors as anticancer agents. 2000 1
133 10632369 Specificity of alpha-cyano-beta-hydroxy-beta-methyl-n-[4-(trifluoromethoxy)phe nyl]-propenamide as an inhibitor of the epidermal growth factor receptor tyrosine kinase. 1999 Dec 1
134 9287333 Unliganded epidermal growth factor receptor dimerization induced by direct interaction of quinazolines with the ATP binding site. 1997 Sep 12 7