Title : ErbB/HER protein-tyrosine kinases: Structures and small molecule inhibitors.

Pub. Date : 2014 Sep

PMID : 24928736






1 Functional Relationships(s)
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1 Gefitinib, erlotinib, and afatinib are orally effective protein-kinase targeted quinazoline derivatives that are used in the treatment of ERBB1-mutant lung cancer and lapatinib is an orally effective quinazoline derivative used in the treatment of ErbB2-overexpressing breast cancer. Quinazolines epidermal growth factor receptor Homo sapiens