Berberine

AKT serine/threonine kinase 1 ; Homo sapiens







59 Article(s)
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1 34348611 Berberine in the Treatment of Neurodegenerative Diseases and Nanotechnology Enabled Targeted Delivery. 2022 1
2 34935059 Berberine enhances gemcitabine‑induced cytotoxicity in bladder cancer by downregulating Rad51 expression through inactivating the PI3K/Akt pathway. 2022 Feb 4
3 35600365 Berberine and Oligomeric Proanthocyanidins Exhibit Synergistic Efficacy Through Regulation of PI3K-Akt Signaling Pathway in Colorectal Cancer. 2022 1
4 32988344 Berberine Exerts Anti-cancer Activity by Modulating Adenosine Monophosphate- Activated Protein Kinase (AMPK) and the Phosphatidylinositol 3-Kinase/ Protein Kinase B (PI3K/AKT) Signaling Pathways. 2021 3
5 33325633 Dual down-regulation of EGFR and ErbB2 by berberine contributes to suppression of migration and invasion of human ovarian cancer cells. 2021 May 1
6 33417512 Berberine regulates the Notch1/PTEN/PI3K/AKT/mTOR pathway and acts synergistically with 17-AAG and SAHA in SW480 colon cancer cells. 2021 Dec 2
7 34643248 Berberine exerts its antineoplastic effects by reversing the Warburg effect via downregulation of the Akt/mTOR/GLUT1 signaling pathway. 2021 Dec 5
8 34712379 Berberine Suppresses EMT in Liver and Gastric Carcinoma Cells through Combination with TGFβR Regulating TGF-β/Smad Pathway. 2021 2
9 34981469 Evaluation of the Effects of Nanomicellar Curcumin, Berberine, and Their Combination with 5-Fluorouracil on Breast Cancer Cells. 2021 1
10 30902523 Berberine and musculoskeletal disorders: The therapeutic potential and underlying molecular mechanisms. 2020 Jul 15 1
11 31688419 Berberine alleviates rotenone-induced cytotoxicity by antioxidation and activation of PI3K/Akt signaling pathway in SH-SY5Y cells. 2020 Jan 8 3
12 32184626 Berberine Reverses Doxorubicin Resistance by Inhibiting Autophagy Through the PTEN/Akt/mTOR Signaling Pathway in Breast Cancer. 2020 2
13 32245062 Recent Advances in Berberine Inspired Anticancer Approaches: From Drug Combination to Novel Formulation Technology and Derivatization. 2020 Mar 20 1
14 32256641 Mechanisms of Berberine for the Treatment of Atherosclerosis Based on Network Pharmacology. 2020 1
15 32445451 AMPK and its Activator Berberine in the Treatment of Neurodegenerative Diseases. 2020 1
16 32454290 Berberine represses human gastric cancer cell growth in vitro and in vivo by inducing cytostatic autophagy via inhibition of MAPK/mTOR/p70S6K and Akt signaling pathways. 2020 Aug 4
17 32682817 Berberine and Emodin abrogates breast cancer growth and facilitates apoptosis through inactivation of SIK3-induced mTOR and Akt signaling pathway. 2020 Nov 1 1
18 32969153 Immunomodulatory effects of berberine on the inflamed joint reveal new therapeutic targets for rheumatoid arthritis management. 2020 Nov 1
19 33362566 Berberine Improves Chemo-Sensitivity to Cisplatin by Enhancing Cell Apoptosis and Repressing PI3K/AKT/mTOR Signaling Pathway in Gastric Cancer. 2020 3
20 33426081 Exploring the Antitumor Mechanisms of Zingiberis Rhizoma Combined with Coptidis Rhizoma Using a Network Pharmacology Approach. 2020 2
21 30343043 Antitumor effects of berberine against EGFR, ERK1/2, P38 and AKT in MDA-MB231 and MCF-7 breast cancer cells using molecular modelling and in vitro study. 2019 Feb 4
22 30911957 Berberine enhances posttranslational protein stability of p21/cip1 in breast cancer cells via down-regulation of Akt. 2019 Aug 3
23 31111379 Berberine mitigates IL-21/IL-21R mediated autophagic influx in fibroblast-like synoviocytes and regulates Th17/Treg imbalance in rheumatoid arthritis. 2019 Aug 3
24 31545468 Exploring the active mechanism of berberine against HCC by systematic pharmacology and experimental validation. 2019 Nov 7
25 31841506 Combination treatment of berberine and solid lipid curcumin particles increased cell death and inhibited PI3K/Akt/mTOR pathway of human cultured glioblastoma cells more effectively than did individual treatments. 2019 1
26 29360760 Regulation of Akt/FoxO3a/Skp2 Axis Is Critically Involved in Berberine-Induced Cell Cycle Arrest in Hepatocellular Carcinoma Cells. 2018 Jan 23 2
27 29477657 Berberine induces miR-373 expression in hepatocytes to inactivate hepatic steatosis associated AKT-S6 kinase pathway. 2018 Apr 15 1
28 29626488 Berberine induced modulation of PHLPP2-Akt-MST1 kinase signaling is coupled with mitochondrial impairment and hepatoma cell death. 2018 May 15 2
29 29732634 Berberine: Pathways to protect neurons. 2018 Aug 1
30 29790698 Inhibition of migration and invasion by berberine via inactivation of PI3K/Akt and p38 in human retinoblastoma cell line. 2018 Jul 3
31 30087941 Drug-Carrying Capacity and Anticancer Effect of the Folic Acid- and Berberine-Loaded Silver Nanomaterial To Regulate the AKT-ERK Pathway in Breast Cancer. 2018 Jul 31 1
32 30272344 Berberine promotes nerve regeneration through IGFR‑mediated JNK‑AKT signal pathway. 2018 Dec 3
33 28931215 Berberine could inhibit thyroid carcinoma cells by inducing mitochondrial apoptosis, G0/G1 cell cycle arrest and suppressing migration via PI3K-AKT and MAPK signaling pathways. 2017 Nov 1
34 29118901 Impacts of berberine on oxidized LDL-induced proliferation of human umbilical vein endothelial cells. 2017 1
35 26672764 Melatonin inhibits AP-2β/hTERT, NF-κB/COX-2 and Akt/ERK and activates caspase/Cyto C signaling to enhance the antitumor activity of berberine in lung cancer cells. 2016 Jan 19 3
36 27398330 Berberine Induced Apoptosis of Human Osteosarcoma Cells by Inhibiting Phosphoinositide 3 Kinase/Protein Kinase B (PI3K/Akt) Signal Pathway Activation. 2016 May 4
37 25837881 Akt signaling is associated with the berberine-induced apoptosis of human gastric cancer cells. 2015 6
38 26087719 Berberine Sensitizes Human Ovarian Cancer Cells to Cisplatin Through miR-93/PTEN/Akt Signaling Pathway. 2015 2
39 24905527 Berberine inhibits LPS-induced TF procoagulant activity and expression through NF-κB/p65, Akt and MAPK pathway in THP-1 cells. 2014 Jun 2
40 25128467 FoxO proteins' nuclear retention and BH3-only protein Bim induction evoke mitochondrial dysfunction-mediated apoptosis in berberine-treated HepG2 cells. 2014 Nov 1
41 25257463 Berberine protects endothelial progenitor cell from damage of TNF-α via the PI3K/AKT/eNOS signaling pathway. 2014 Nov 15 5
42 25279238 Inhibitory Effects of Isoquinoline Alkaloid Berberine on Ischemia-Induced Apoptosis via Activation of Phosphoinositide 3-Kinase/Protein Kinase B Signaling Pathway. 2014 Sep 2
43 26168133 Induction of G₂/M Arrest by Berberine via Activation of PI3K/Akt and p38 in Human Chondrosarcoma Cell Line. 2014 4
44 23329300 Berberine protects 6-hydroxydopamine-induced human dopaminergic neuronal cell death through the induction of heme oxygenase-1. 2013 Feb 1
45 23732865 Berberine induces selective apoptosis through the AMPK‑mediated mitochondrial/caspase pathway in hepatocellular carcinoma. 2013 Aug 1
46 23954465 Berberine, a natural antidiabetes drug, attenuates glucose neurotoxicity and promotes Nrf2-related neurite outgrowth. 2013 Nov 1 1
47 24335179 Berberine suppresses TPA-induced fibronectin expression through the inhibition of VEGF secretion in breast cancer cells. 2013 1
48 22950834 Berberine, an isoquinoline alkaloid, inhibits the metastatic potential of breast cancer cells via Akt pathway modulation. 2012 Sep 26 2
49 21110076 Berberine inhibits inflammatory response and ameliorates insulin resistance in hepatocytes. 2011 Dec 1
50 21699261 Growth suppression of HER2-overexpressing breast cancer cells by berberine via modulation of the HER2/PI3K/Akt signaling pathway. 2011 Aug 10 1