Pub. Date : 2019 Nov
PMID : 31545468
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Through systematic pharmacological analysis, it was found that BBR serves a significant role in inhibiting HCC by affecting multiple pathways, especially the PI3K/AKT signaling pathway. | Berberine | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Furthermore, the docking approach indicated that the binding of BBR to AKT could lead to the suppression of AKT activity. | Berberine | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Furthermore, the docking approach indicated that the binding of BBR to AKT could lead to the suppression of AKT activity. | Berberine | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | The present study examined the inhibitory effect of BBR on the PI3K/AKT pathway in HCC and identified that BBR downregulated the expressions of phosphorylated AKT and PI3K in MHCC97-H and HepG2 cells, inhibiting their growth, cell migration and invasion in a dose-dependent manner. | Berberine | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | The present study examined the inhibitory effect of BBR on the PI3K/AKT pathway in HCC and identified that BBR downregulated the expressions of phosphorylated AKT and PI3K in MHCC97-H and HepG2 cells, inhibiting their growth, cell migration and invasion in a dose-dependent manner. | Berberine | AKT serine/threonine kinase 1 | Homo sapiens |
| 6 | In addition, inhibition of the AKT pathway by BBR also contributed to cell apoptosis in MHCC97-H and HepG2 cells. | Berberine | AKT serine/threonine kinase 1 | Homo sapiens |
| 7 | Taken together, the results of the present study suggested that BBR may be a promising antitumor drug for HCC that acts by inhibiting the PI3K/AKT pathway. | Berberine | AKT serine/threonine kinase 1 | Homo sapiens |