Pub. Date : 2020 Aug
PMID : 32454290
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Berberine represses human gastric cancer cell growth in vitro and in vivo by inducing cytostatic autophagy via inhibition of MAPK/mTOR/p70S6K and Akt signaling pathways. | Berberine | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Mechanistic studies showed that berberine inhibited mTOR, Akt and MAPK (ERK, JNK and p38) pathways thereby inducing autophagy. | Berberine | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Furthermore, inhibition of autophagy reversed berberine down-regulated mTOR, Akt and MAPK. | Berberine | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Briefly, these results indicated that berberine repressed human gastric cancer cell growth in vitro and in vivo by inducing cytostatic autophagy via inhibition of MAPK/mTOR/p70S6K and Akt, and provided a molecular basis for the treatment of gastric cancer. | Berberine | AKT serine/threonine kinase 1 | Homo sapiens |