Pub. Date : 2014 Nov 15
PMID : 25257463
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Berberine protects endothelial progenitor cell from damage of TNF-alpha via the PI3K/AKT/eNOS signaling pathway. | Berberine | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | The aim of this study was to investigate whether berberine (BBR) can protect EPCs from the inhibition caused by TNF-alpha via the PI3K (Phosphatidyl Inositol 3-kinase) /AKT (Serine/threonine protein kinase B) /eNOS (endothelial Nitric Oxide synthase) signaling pathway. | Berberine | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | The aim of this study was to investigate whether berberine (BBR) can protect EPCs from the inhibition caused by TNF-alpha via the PI3K (Phosphatidyl Inositol 3-kinase) /AKT (Serine/threonine protein kinase B) /eNOS (endothelial Nitric Oxide synthase) signaling pathway. | Berberine | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | BBR can increase the level of PI3K/Akt/eNOS mRNA and the protein level of PI3K, p-Akt, eNOS and p-eNOS, which can be blocked by PI3K inhibitor (LY294002) and eNOS inhibitor (l-NAME). | Berberine | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | BBR can increase the level of PI3K/Akt/eNOS mRNA and the protein level of PI3K, p-Akt, eNOS and p-eNOS, which can be blocked by PI3K inhibitor (LY294002) and eNOS inhibitor (l-NAME). | Berberine | AKT serine/threonine kinase 1 | Homo sapiens |