Tamoxifen

AKT serine/threonine kinase 1 ; Homo sapiens







118 Article(s)
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1 34287884 Retraction. 2022 Mar 1
2 34969766 Cholesterol Depletion Modulates Drug Resistance Pathways to Sensitize Resistant Breast Cancer Cells to Tamoxifen. 2022 Jan 3
3 35054486 Overexpression of BQ323636.1 Modulated AR/IL-8/CXCR1 Axis to Confer Tamoxifen Resistance in ER-Positive Breast Cancer. 2022 Jan 10 1
4 35066343 13-Methyl-palmatrubine shows an anti-tumor role in non-small cell lung cancer via shifting M2 to M1 polarization of tumor macrophages. 2022 Mar 1
5 35125086 Nimbolide, a Neem Limonoid, Inhibits Angiogenesis in Breast Cancer by Abrogating Aldose Reductase Mediated IGF-1/PI3K/Akt Signalling. 2022 1
6 35169858 Inhibition of the VEGF signaling pathway attenuates tumor‑associated macrophage activity in liver cancer. 2022 Apr 2
7 35559394 LncRNA TTN-AS1 confers tamoxifen resistance in breast cancer via sponging miR-107 to modulate PI3K/AKT signaling pathway. 2022 2
8 33755174 Fatty acid oxidation and autophagy promote endoxifen resistance and counter the effect of AKT inhibition in ER-positive breast cancer cells. 2021 Sep 11 1
9 33800852 Fatty Acid Synthase Confers Tamoxifen Resistance to ER+/HER2+ Breast Cancer. 2021 Mar 6 1
10 33861751 CSNK1G2 differently sensitizes tamoxifen-induced decrease in PI3K/AKT/mTOR/S6K and ERK signaling according to the estrogen receptor existence in breast cancer cells. 2021 3
11 34149926 HOXA5 confers tamoxifen resistance via the PI3K/AKT signaling pathway in ER-positive breast cancer. 2021 1
12 34182538 GPR30-mediated HMGB1 upregulation in CAFs induces autophagy and tamoxifen resistance in ERα-positive breast cancer cells. 2021 Jun 28 1
13 34326682 Cx43 deficiency confers EMT-mediated tamoxifen resistance to breast cancer via c-Src/PI3K/Akt pathway. 2021 2
14 34370280 PI3K/AKT and MAPK1 molecular changes preceding matrix metallopeptidases overexpression during tamoxifen-resistance development are correlated to poor prognosis in breast cancer patients. 2021 Nov 5
15 34424807 Long non-coding RNA FOXD3 antisense RNA 1 augments anti-estrogen resistance in breast cancer cells through the microRNA-363/ trefoil factor 1/ phosphatidylinositol 3-kinase/protein kinase B axis. 2021 Dec 1
16 34619972 Tumor-associated macrophages increase COX-2 expression promoting endocrine resistance in breast cancer via the PI3K/Akt/mTOR pathway. 2021 Sep 1
17 34771077 Towards Unravelling the Role of ERα-Targeting miRNAs in the Exosome-Mediated Transferring of the Hormone Resistance. 2021 Nov 3 1
18 31604073 Knockdown of PTEN decreases expression of estrogen receptor β and tamoxifen sensitivity of human breast cancer cells. 2020 Jan 1
19 31710162 Tumor-associated macrophages secrete CC-chemokine ligand 2 and induce tamoxifen resistance by activating PI3K/Akt/mTOR in breast cancer. 2020 Jan 1
20 31894313 Metformin alleviates endometrial hyperplasia through the UCA1/miR‑144/TGF‑β1/AKT signaling pathway. 2020 Feb 1
21 32417506 CXCL10 mediates breast cancer tamoxifen resistance and promotes estrogen-dependent and independent proliferation. 2020 Jul 15 1
22 32668964 MLL3 Induced by Luteolin Causes Apoptosis in Tamoxifen-Resistant Breast Cancer Cells through H3K4 Monomethylation and Suppression of the PI3K/AKT/mTOR Pathway. 2020 1
23 32691010 CXCR4 Antagonist AMD3100 Reverses the Resistance to Tamoxifen in Breast Cancer via Inhibiting AKT Phosphorylation. 2020 Sep 25 1
24 32921987 Fatostatin in Combination with Tamoxifen Induces Synergistic Inhibition in ER-Positive Breast Cancer. 2020 2
25 33177647 Coffee decoction enhances tamoxifen proapoptotic activity on MCF-7 cells. 2020 Nov 11 1
26 33318536 Upregulation of PI3K/AKT/PTEN pathway is correlated with glucose and glutamine metabolic dysfunction during tamoxifen resistance development in MCF-7 cells. 2020 Dec 14 5
27 30145819 Inhibitory role of large intergenic noncoding RNA-ROR on tamoxifen resistance in the endocrine therapy of breast cancer by regulating the PI3K/Akt/mTOR signaling pathway. 2019 Feb 5
28 30304547 Tamoxifen ameliorates obstructive nephropathy through Src and the PI3K/Akt/mTOR pathway. 2019 Jan 5
29 30680659 Dissecting the predictive value of MAPK/AKT/estrogen-receptor phosphorylation axis in primary breast cancer to treatment response for tamoxifen over exemestane: a Translational Report of the Intergroup Exemestane Study (IES)-PathIES. 2019 May 1
30 30795784 Aberrant fatty acid profile and FFAR4 signaling confer endocrine resistance in breast cancer. 2019 Feb 22 1
31 30890553 Breast Phyllodes Tumors Recruit and Repolarize Tumor-Associated Macrophages via Secreting CCL5 to Promote Malignant Progression, Which Can Be Inhibited by CCR5 Inhibition Therapy. 2019 Jul 1 1
32 31088266 Colon Cancer Cell Secretes EGF to Promote M2 Polarization of TAM Through EGFR/PI3K/AKT/mTOR Pathway. 2019 Jan 1 1
33 31202170 MMP-9 secreted by tumor associated macrophages promoted gastric cancer metastasis through a PI3K/AKT/Snail pathway. 2019 Sep 1
34 31657150 Epigenetic silencing of SALL2 confers tamoxifen resistance in breast cancer. 2019 Dec 1
35 29248549 A role of SIPL1/SHARPIN in promoting resistance to hormone therapy in breast cancer. 2018 Mar 1
36 29620287 Protein arginine N-methyltransferase 2 reverses tamoxifen resistance in breast cancer cells through suppression of ER-α36. 2018 Jun 1
37 29787277 Targeting of EGFR, VEGFR2, and Akt by Engineered Dual Drug Encapsulated Mesoporous Silica-Gold Nanoclusters Sensitizes Tamoxifen-Resistant Breast Cancer. 2018 Jul 2 3
38 29945962 Loss of Estrogen-Regulated MIR135A1 at 3p21.1 Promotes Tamoxifen Resistance in Breast Cancer. 2018 Sep 1 1
39 30076704 AhR ligand aminoflavone suppresses α6-integrin-Src-Akt signaling to attenuate tamoxifen resistance in breast cancer cells. 2018 Jan 2
40 30154367 SET Overexpression is Associated with Worse Recurrence-Free Survival in Patients with Primary Breast Cancer Receiving Adjuvant Tamoxifen Treatment. 2018 Aug 28 2
41 27838413 MCAM/CD146 promotes tamoxifen resistance in breast cancer cells through induction of epithelial-mesenchymal transition, decreased ERα expression and AKT activation. 2017 Feb 1 2
42 28852212 Phosphatidylinositol-3 Kinase Inhibitors, Buparlisib and Alpelisib, Sensitize Estrogen Receptor-positive Breast Cancer Cells to Tamoxifen. 2017 Aug 29 2
43 28855026 Fibronectin expression is upregulated by PI-3K/Akt activation in tamoxifen-resistant breast cancer cells. 2017 Dec 3
44 29179465 Shikonin reduces tamoxifen resistance through long non-coding RNA uc.57. 2017 Oct 24 2
45 26892736 The phenomenon of acquired resistance to metformin in breast cancer cells: The interaction of growth pathways and estrogen receptor signaling. 2016 Apr 1
46 27027343 Huaier extract synergizes with tamoxifen to induce autophagy and apoptosis in ER-positive breast cancer cells. 2016 May 3 1
47 27262235 Tamoxifen-induced cytotoxicity in breast cancer cells is mediated by glucose-regulated protein 78 (GRP78) via AKT (Thr308) regulation. 2016 Aug 8
48 27633191 Determination of the optimal time for tamoxifen treatment in combination with radiotherapy. 2016 Nov 2
49 25490383 Down-regulation of MSH2 expression by Hsp90 inhibition enhances cytotoxicity affected by tamoxifen in human lung cancer cells. 2015 Jan 2 1
50 25727020 Omega-3 free fatty acids inhibit tamoxifen-induced cell apoptosis. 2015 Apr 3 3