Pub. Date : 2015 Apr 3
PMID : 25727020
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | omega-3FFA and tamoxifen significantly increased Erk1/2 and Akt phosphorylation levels in a dose and time dependent manner. | Tamoxifen | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Compared to omega-3FFA alone, the combination of tamoxifen with omega-3FFA significantly increased Erk1/2 and Akt phosphorylation levels. | Tamoxifen | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Because Erk1/2 and Akt activation has been linked to tamoxifen-related anti-estrogen resistance in breast cancer patients, these results indicate that omega-3FFA may interfere with the effects of tamoxifen in the prevention of breast cancer risk. | Tamoxifen | AKT serine/threonine kinase 1 | Homo sapiens |