Title : Cholesterol Depletion Modulates Drug Resistance Pathways to Sensitize Resistant Breast Cancer Cells to Tamoxifen.

Pub. Date : 2022 Jan

PMID : 34969766






3 Functional Relationships(s)
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1 CONCLUSION: The present study demonstrates the efficacy of tamoxifen combined with acetyl plumbagin in potentially disrupting the PI3K/Akt/PKB and Akt/mTORC1 signalling pathways in MCF-7 cells, reducing breast cancer cell proliferation and resistance. Tamoxifen AKT serine/threonine kinase 1 Homo sapiens
2 CONCLUSION: The present study demonstrates the efficacy of tamoxifen combined with acetyl plumbagin in potentially disrupting the PI3K/Akt/PKB and Akt/mTORC1 signalling pathways in MCF-7 cells, reducing breast cancer cell proliferation and resistance. Tamoxifen AKT serine/threonine kinase 1 Homo sapiens
3 CONCLUSION: The present study demonstrates the efficacy of tamoxifen combined with acetyl plumbagin in potentially disrupting the PI3K/Akt/PKB and Akt/mTORC1 signalling pathways in MCF-7 cells, reducing breast cancer cell proliferation and resistance. Tamoxifen AKT serine/threonine kinase 1 Homo sapiens