Pub. Date : 2018 Jan
PMID : 30076704
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Emerging evidence suggests tumor initiating cells (TICs) and aberrant activation of Src and Akt signaling drive tamoxifen resistance and relapse. | Tamoxifen | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | In the current study, we hypothesize that tamoxifen-resistant (TamR) cells exhibit higher levels of alpha6-integrin than tamoxifen-sensitive cells and that AF inhibits the growth of TamR cells by suppressing alpha6-integrin-Src-Akt signaling. | Tamoxifen | AKT serine/threonine kinase 1 | Homo sapiens |