Title : The phenomenon of acquired resistance to metformin in breast cancer cells: The interaction of growth pathways and estrogen receptor signaling.

Pub. Date : 2016 Apr

PMID : 26892736






1 Functional Relationships(s)
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1 Importantly, the acquired resistance to both drugs is based on the constitutive activation of Akt/Snail1/E-cadherin signaling that opens new perspectives to overcome the metformin/tamoxifen resistance of breast cancer. Tamoxifen AKT serine/threonine kinase 1 Homo sapiens