Title : MMP-9 secreted by tumor associated macrophages promoted gastric cancer metastasis through a PI3K/AKT/Snail pathway.

Pub. Date : 2019 Sep

PMID : 31202170






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1 CONCLUSION: Our data showed that TAMs facilitate the EMT process via an MMP-9/PI3K/AKT/Snail dependent pathway, while blocking this signaling pathway with MMP-9 proenzyme inhibitor could suppress distant metastasis in gastric cancer. Tamoxifen AKT serine/threonine kinase 1 Homo sapiens