Superoxides

AKT serine/threonine kinase 1 ; Homo sapiens







80 Article(s)
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1 33827604 Ruthenium-loaded mesoporous silica as tumor microenvironment-response nano-fenton reactors for precise cancer therapy. 2021 Apr 7 1
2 31648572 Radiosensitizing Potential of Curcumin in Different Cancer Models. 2020 1
3 31729001 Cell-Free NADPH Oxidase Activation Assays: A Triumph of Reductionism. 2020 2
4 32222623 Mitochondrial superoxide mediates PM2.5-induced cytotoxicity in human pulmonary lymphatic endothelial cells. 2020 Aug 1
5 30804795 Shear Stress Ameliorates Superoxide Impairment to Erythrocyte Deformability With Concurrent Nitric Oxide Synthase Activation. 2019 3
6 26840531 Dual-Functional Nanographene Oxide as Cancer-Targeted Drug-Delivery System to Selectively Induce Cancer-Cell Apoptosis. 2016 Apr 5 1
7 27687768 Angiotensin-(1-7) abrogates angiotensin II-induced proliferation, migration and inflammation in VSMCs through inactivation of ROS-mediated PI3K/Akt and MAPK/ERK signaling pathways. 2016 Sep 30 1
8 27847869 Dysfunctional MnSOD leads to redox dysregulation and activation of prosurvival AKT signaling in uterine leiomyomas. 2016 Nov 1
9 25699251 The dehydrogenase region of the NADPH oxidase component Nox2 acts as a protein disulfide isomerase (PDI) resembling PDIA3 with a role in the binding of the activator protein p67 (phox.). 2015 1
10 25841779 Transforming growth factor ╬▓-interacting factor-induced malignant progression of hepatocellular carcinoma cells depends on superoxide production from Nox4. 2015 Jul 1
11 24504963 Cell-free NADPH oxidase activation assays: "in vitro veritas". 2014 1
12 24561578 OxLDL induces endothelial dysfunction and death via TRAF3IP2: inhibition by HDL3 and AMPK activators. 2014 May 1
13 24598074 Role of the Rho GTPase Rac in the activation of the phagocyte NADPH oxidase: outsourcing a key task. 2014 1
14 24601882 Protein kinase B (PKB/AKT1) formed signaling complexes with mitochondrial proteins and prevented glycolytic energy dysfunction in cultured cardiomyocytes during ischemia-reperfusion injury. 2014 May 1
15 25056956 Arachidonic acid induces direct interaction of the p67(phox)-Rac complex with the phagocyte oxidase Nox2, leading to superoxide production. 2014 Sep 5 1
16 23613809 Superoxide mediates direct current electric field-induced directional migration of glioma cells through the activation of AKT and ERK. 2013 2
17 22519881 Activation of PPAR╬┤ counteracts angiotensin II-induced ROS generation by inhibiting rac1 translocation in vascular smooth muscle cells. 2012 Jul 1
18 22728270 TG-interacting factor-induced superoxide production from NADPH oxidase contributes to the migration/invasion of urothelial carcinoma. 2012 Aug 15 5
19 20945388 5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,7-dimethoxy-4H-chromen-4-one (MSF-2) suppresses fMLP-mediated respiratory burst in human neutrophils by inhibiting phosphatidylinositol 3-kinase activity. 2011 Jun 1
20 21300668 Equol-stimulated mitochondrial reactive oxygen species activate endothelial nitric oxide synthase and redox signaling in endothelial cells: roles for F-actin and GPR30. 2011 Apr 2
21 21418589 The scavenging of superoxide radicals promotes apoptosis induced by a novel cell-permeable fusion protein, sTRAIL:FeSOD, in tumor necrosis factor-related apoptosis-inducing ligand-resistant leukemia cells. 2011 Mar 19 2
22 21460183 Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain. 2011 May 15 1
23 21724868 Suppression of eNOS-derived superoxide by caveolin-1: a biopterin-dependent mechanism. 2011 Sep 1
24 19740072 Statins have beneficial effects on platelet free radical activity and intracellular distribution of GTPases in hyperlipidaemia. 2010 Mar 1
25 20007513 GTPase-Rac enhances depolarization-induced superoxide production by the macula densa during tubuloglomerular feedback. 2010 Feb 2
26 20074642 Characterization of P-Rex1 for its role in fMet-Leu-Phe-induced superoxide production in reconstituted COS(phox) cells. 2010 May 3
27 19457567 Apoptotic body engulfment by hepatic stellate cells promotes their survival by the JAK/STAT and Akt/NF-kappaB-dependent pathways. 2009 Jul 1
28 20375610 The domain organization of p67 phox, a protein required for activation of the superoxide-producing NADPH oxidase in phagocytes. 2009 1
29 18289643 Neutrophil CD40 enhances platelet-mediated inflammation. 2008 1
30 18386220 Xanthine oxidase interaction with vascular endothelial growth factor in human endothelial cell angiogenesis. 2008 Apr 1
31 18480413 Phospholipase D activity regulates integrin-mediated cell spreading and migration by inducing GTP-Rac translocation to the plasma membrane. 2008 Jul 1
32 18505730 Dissociation of Rac1(GDP).RhoGDI complexes by the cooperative action of anionic liposomes containing phosphatidylinositol 3,4,5-trisphosphate, Rac guanine nucleotide exchange factor, and GTP. 2008 Aug 8 1
33 18622039 Phosphorylation of endothelial nitric-oxide synthase regulates superoxide generation from the enzyme. 2008 Oct 3 1
34 18678787 Roles of phosphatidylinositol 3-kinase-Akt and NADPH oxidase in adenosine 5'-triphosphate-sensitive K+ channel function impaired by high glucose in the human artery. 2008 Sep 1
35 17060455 The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity. 2007 Jan 1
36 17318262 Overexpression of Akt converts radial growth melanoma to vertical growth melanoma. 2007 Mar 1
37 17516238 8-oxo-7,8-dihydroguanosine triphosphate(8-oxoGTP) down-regulates respiratory burst of neutrophils by antagonizing GTP toward Rac, a small GTP binding protein. 2007 Jun 1
38 16551617 Molecular cloning and functional characterization of a cell-permeable superoxide dismutase targeted to lung adenocarcinoma cells. Inhibition cell proliferation through the Akt/p27kip1 pathway. 2006 May 12 1
39 16762923 Direct involvement of the small GTPase Rac in activation of the superoxide-producing NADPH oxidase Nox1. 2006 Aug 4 3
40 16987008 Regulation of novel superoxide-producing NAD(P)H oxidases. 2006 Sep-Oct 1
41 17050190 Phagocytosis-coupled activation of the superoxide-producing phagocyte oxidase, a member of the NADPH oxidase (nox) family. 2006 Oct 1
42 15949904 Alternative mRNA splice forms of NOXO1: differential tissue expression and regulation of Nox1 and Nox3. 2005 Aug 15 1
43 14676270 GTPases and reactive oxygen species: switches for killing and signaling. 2004 Jan 15 2
44 14765128 The phagocyte NADPH oxidase depends on cholesterol-enriched membrane microdomains for assembly. 2004 Feb 25 1
45 15100319 Phosphoinositide 3-kinase and Akt occupy central roles in inflammatory responses of Toll-like receptor 2-stimulated neutrophils. 2004 May 1 1
46 15375300 Effects of statins on endothelium and signaling mechanisms. 2004 Nov 2
47 12475976 The guanine nucleotide exchange factor trio activates the phagocyte NADPH oxidase in the absence of GDP to GTP exchange on Rac. "The emperor's nw clothes". 2003 Feb 14 1
48 12483106 Regulation of neutrophil function by Rac GTPases. 2003 Jan 1
49 12734380 Akt phosphorylates p47phox and mediates respiratory burst activity in human neutrophils. 2003 May 15 1
50 12958025 Rac regulates cardiovascular superoxide through diverse molecular interactions: more than a binary GTP switch. 2003 Oct 3