Title : Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain.

Pub. Date : 2011 May 15

PMID : 21460183






1 Functional Relationships(s)
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1 The increased superoxide content induces c-Jun N-terminal kinase 1 (JNK1) kinase activity, which in turn affects FOXO localization through a compensatory dephosphorylation of Akt. Superoxides AKT serine/threonine kinase 1 Homo sapiens