Pub. Date : 2012 Aug 15
PMID : 22728270
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Overexpression of AKT1 could increase cellular superoxide production and invasion. | Superoxides | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Moreover, by using the PI3K/AKT inhibitor wortmannin or shRNA of AKT1, the TGIF-induced Nox activation and superoxide production were significantly inhibited. | Superoxides | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Moreover, by using the PI3K/AKT inhibitor wortmannin or shRNA of AKT1, the TGIF-induced Nox activation and superoxide production were significantly inhibited. | Superoxides | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Accordingly, we suggest that PI3K/AKT signaling mediates TGIF-induced Nox2/p67(phox) complex activation and the resultant superoxide production which reinforces the PI3K/AKT signaling to promote the cellular migration/invasion ability of UC. | Superoxides | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | Accordingly, we suggest that PI3K/AKT signaling mediates TGIF-induced Nox2/p67(phox) complex activation and the resultant superoxide production which reinforces the PI3K/AKT signaling to promote the cellular migration/invasion ability of UC. | Superoxides | AKT serine/threonine kinase 1 | Homo sapiens |