Pub. Date : 2019
PMID : 30804795
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In addition, RBC exposed to O2 - were conditioned with specific shear stresses, prior to evaluation of cellular deformability and activation of PI3K/Akt kinase and RBC-NOS. | Superoxides | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Intracellular generation of O2 - decreased phosphorylation of RBC-NOS at its primary activation site (Ser1177) (p < 0.001), while phosphorylation of Akt kinase at its active residue (Ser473) was also diminished (p < 0.001). | Superoxides | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Impaired RBC deformability induced by intracellular O2 - may be due, in part, to impaired activation of PI3K/Akt, and downstream signaling with RBC-NOS. | Superoxides | AKT serine/threonine kinase 1 | Homo sapiens |