Oxaliplatin

tumor protein p53 ; Homo sapiens







90 Article(s)
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1 34785775 Inhibition of cathepsin K sensitizes oxaliplatin-induced apoptotic cell death by Bax upregulation through OTUB1-mediated p53 stabilization in vitro and in vivo. 2022 Jan 2
2 35165262 DNAJB8 in small extracellular vesicles promotes Oxaliplatin resistance through TP53/MDR1 pathway in colon cancer. 2022 Feb 14 3
3 35178443 Aldehyde Dehydrogenase 2 Family Member (ALDH2) Is a Therapeutic Index for Oxaliplatin Response on Colorectal Cancer Therapy with Dysfunction p53. 2022 5
4 35584569 BAP1 phosphorylation-mediated Sp1 stabilization plays a critical role in cathepsin K inhibition-induced C-terminal p53-dependent Bax upregulation. 2022 Jul 1
5 33662352 Perifosine enhances the potential antitumor effect of 5-fluorourasil and oxaliplatin in colon cancer cells harboring the PIK3CA mutation. 2021 May 5 2
6 33824865 TRIM29 Reverses Oxaliplatin Resistance of P53 Mutant Colon Cancer Cell. 2021 7
7 33922007 Oxaliplatin-Induced Senescence in Colorectal Cancer Cells Depends on p14ARF-Mediated Sustained p53 Activation. 2021 Apr 22 6
8 33963708 [Synergistic effect of polysaccharide from Trichoderma pseudokoningii and oxaliplatin on colorectal cancer cells in vitro]. 2021 Apr 20 1
9 33986248 A KLF4/PiHL/EZH2/HMGA2 regulatory axis and its function in promoting oxaliplatin-resistance of colorectal cancer. 2021 May 13 1
10 32163218 Curcumin β-D-glucuronide exhibits anti-tumor effects on oxaliplatin-resistant colon cancer with less toxicity in vivo. 2020 May 2
11 32468080 Protein expression profiling identifies differential modulation of homologous recombination by platinum-based antitumor agents. 2020 Jun 2
12 32622356 Gallbladder cancer with EGFR mutation and its response to GemOx with erlotinib: a case report and review of literature. 2020 Jul 4 1
13 32742376 TP53 mutation influences the efficacy of treatment of colorectal cancer cell lines with a combination of sirtuin inhibitors and chemotherapeutic agents. 2020 Aug 1
14 32851091 AURKA Increase the Chemosensitivity of Colon Cancer Cells to Oxaliplatin by Inhibiting the TP53-Mediated DNA Damage Response Genes. 2020 1
15 32984059 Dysregulated Phosphorylation of p53, Autophagy and Stemness Attributes the Mutant p53 Harboring Colon Cancer Cells Impaired Sensitivity to Oxaliplatin. 2020 4
16 33251049 LINC00460-miR-149-5p/miR-150-5p-Mutant p53 Feedback Loop Promotes Oxaliplatin Resistance in Colorectal Cancer. 2020 Dec 4 5
17 30418550 Urolithin A gains in antiproliferative capacity by reducing the glycolytic potential via the p53/TIGAR axis in colon cancer cells. 2019 Mar 12 1
18 30596962 Oligomeric proanthocyanidins (OPCs) from grape seed extract suppress the activity of ABC transporters in overcoming chemoresistance in colorectal cancer cells. 2019 May 14 1
19 30724469 Serine/arginine protein-specific kinase 2 promotes the development and progression of pancreatic cancer by downregulating Numb and p53. 2019 May 2
20 30792807 Anticancer response to disulfiram may be enhanced by co-treatment with MEK inhibitor or oxaliplatin: modulation by tetrathiomolybdate, KRAS/BRAF mutations and c-MYC/p53 status. 2019 1
21 30894685 p53 expression status is associated with cancer-specific survival in stage III and high-risk stage II colorectal cancer patients treated with oxaliplatin-based adjuvant chemotherapy. 2019 Apr 1
22 30898612 Effects of the MDM-2 inhibitor Nutlin-3a on PDAC cells containing and lacking WT-TP53 on sensitivity to chemotherapy, signal transduction inhibitors and nutraceuticals. 2019 May 1
23 30987009 Luteolin Shifts Oxaliplatin-Induced Cell Cycle Arrest at G₀/G₁ to Apoptosis in HCT116 Human Colorectal Carcinoma Cells. 2019 Apr 2 3
24 31002510 Fuplatin: An Efficient and Low-Toxic Dual-Prodrug. 2019 May 9 1
25 31436301 Dehydrogenase/reductase SDR family member 2 silencing sensitizes an oxaliplatin‑resistant cell line to oxaliplatin by inhibiting excision repair cross‑complementing group 1 protein expression. 2019 Nov 1
26 29115606 DNA methyltransferase 3a modulates chemosensitivity to gemcitabine and oxaliplatin via CHK1 and AKT in p53‑deficient pancreatic cancer cells. 2018 Jan 2
27 29138869 Cepharanthine exhibits a potent anticancer activity in p53-mutated colorectal cancer cells through upregulation of p21Waf1/Cip1. 2018 Jan 1
28 29378575 Effects of Omegaven®, EPA, DHA and oxaliplatin on oesophageal adenocarcinoma cell lines growth, cytokine and cell signal biomarkers expression. 2018 Jan 30 2
29 29896290 A Study on Effect of Oxaliplatin in MicroRNA Expression in Human Colon Cancer. 2018 3
30 29963241 Survivin antagonizes chemotherapy-induced cell death of colorectal cancer cells. 2018 Jun 12 2
31 29980405 Introduction of WT-TP53 into pancreatic cancer cells alters sensitivity to chemotherapeutic drugs, targeted therapeutics and nutraceuticals. 2018 Aug 1
32 30029680 Regulation of tNOX expression through the ROS-p53-POU3F2 axis contributes to cellular responses against oxaliplatin in human colon cancer cells. 2018 Jul 20 16
33 30059758 Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy. 2018 Oct 5
34 28031409 Functional Activation of Mutant p53 by Platinum Analogues in Cisplatin-Resistant Cells Is Dependent on Phosphorylation. 2017 Mar 2
35 28122359 Tumor-associated NADH oxidase (tNOX)-NAD+-sirtuin 1 axis contributes to oxaliplatin-induced apoptosis of gastric cancer cells. 2017 Feb 28 1
36 28284059 Reactivating p53 and Inducing Tumor Apoptosis (RITA) Enhances the Response of RITA-Sensitive Colorectal Cancer Cells to Chemotherapeutic Agents 5-Fluorouracil and Oxaliplatin. 2017 Apr 1
37 28902369 Synergistic inhibitory effects on hepatocellular carcinoma with recombinant human adenovirus Aspp2 and oxaliplatin via p53-independent pathway in vitro and in vivo. 2017 Oct 2
38 27609465 Upregulation of CYP2S1 by oxaliplatin is associated with p53 status in colorectal cancer cell lines. 2016 Sep 9 8
39 25534115 ASPP2 enhances oxaliplatin (L-OHP)-induced colorectal cancer cell apoptosis in a p53-independent manner by inhibiting cell autophagy. 2015 Mar 2
40 26146058 [ASPP2 inhibits oxaliplatin-induced autophagy and promotes apoptosis of colon cancer cells]. 2015 Jul 2
41 26208523 The 1,2-Diaminocyclohexane Carrier Ligand in Oxaliplatin Induces p53-Dependent Transcriptional Repression of Factors Involved in Thymidylate Biosynthesis. 2015 Oct 6
42 26490659 Does anti-p53 antibody status predict for clinical outcomes in metastatic colorectal cancer patients treated with fluoropyrimidine, oxaliplatin, plus bevacizumab as first-line chemotherapy? 2015 Oct 21 1
43 23821376 Lack of KRAS, NRAS, BRAF and TP53 mutations improves outcome of elderly metastatic colorectal cancer patients treated with cetuximab, oxaliplatin and UFT. 2014 Jun 2
44 24634414 Metallothionein 1G and zinc sensitize human colorectal cancer cells to chemotherapy. 2014 May 1
45 25241782 [Phosphorylation status of ASPP2 modulates p53 apoptotic function in oxaliplatin-induced apoptosis of colorectal cancer HCT116 cells]. 2014 Jun 3
46 25474278 Prognostic value of microsatellite instability and p53 expression in metastatic colorectal cancer treated with oxaliplatin and fluoropyrimidine-based chemotherapy. 2014 Dec 2
47 23262037 Negative regulation of transcription factor FoxM1 by p53 enhances oxaliplatin-induced senescence in hepatocellular carcinoma. 2013 Apr 30 2
48 23504997 Suppression of actopaxin impairs hepatocellular carcinoma metastasis through modulation of cell migration and invasion. 2013 Aug 1
49 23525071 Induction of pancreatic cancer cell apoptosis, invasion, migration, and enhancement of chemotherapy sensitivity of gemcitabine, 5-FU, and oxaliplatin by hnRNP A2/B1 siRNA. 2013 Jul 1
50 23754252 Enhanced antitumor activity of cerulenin combined with oxaliplatin in human colon cancer cells. 2013 Aug 3