Pub. Date : 2021
PMID : 33824865
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TRIM29 Reverses Oxaliplatin Resistance of P53 Mutant Colon Cancer Cell. | Oxaliplatin | tumor protein p53 | Homo sapiens |
| 2 | In our experiments, we aim to elucidate the associations among TRIM29 protein, mutant P53, and the resistance of colon cancer cells to oxaliplatin. | Oxaliplatin | tumor protein p53 | Homo sapiens |
| 3 | TRIM29 significantly increased the sensitivity of P53 mutant colon cancer cell HT29 to oxaliplatin. | Oxaliplatin | tumor protein p53 | Homo sapiens |
| 4 | The oxaliplatin-resistant model of P53 mutant colon cancer cell HT29 was successfully constructed. | Oxaliplatin | tumor protein p53 | Homo sapiens |
| 5 | Conclusion: In mutant P53 colon cancer cell HT29, TRIM29 greatly increased the sensitivity of HT29 to oxaliplatin and reverse oxaliplatin resistance. | Oxaliplatin | tumor protein p53 | Homo sapiens |
| 6 | Conclusion: In mutant P53 colon cancer cell HT29, TRIM29 greatly increased the sensitivity of HT29 to oxaliplatin and reverse oxaliplatin resistance. | Oxaliplatin | tumor protein p53 | Homo sapiens |
| 7 | The underlying mechanism is TRIM29 may increase the sensitivity of HT29 to oxaliplatin by blocking the transcriptional function of mutant P53, which inhibits the transcription function of its downstream gene such as MDR1. | Oxaliplatin | tumor protein p53 | Homo sapiens |