Pub. Date : 2016 Sep 9
PMID : 27609465
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Upregulation of CYP2S1 by oxaliplatin is associated with p53 status in colorectal cancer cell lines. | Oxaliplatin | tumor protein p53 | Homo sapiens |
| 2 | In the present study, oxaliplatin was found to strongly inhibit the growth of HCT116 cells harboring wild-type p53 but to only weakly inhibit SW480 cells, HT29 cells or p53-/- HCT116 cells, which all lack p53 expression. | Oxaliplatin | tumor protein p53 | Homo sapiens |
| 3 | In the present study, oxaliplatin was found to strongly inhibit the growth of HCT116 cells harboring wild-type p53 but to only weakly inhibit SW480 cells, HT29 cells or p53-/- HCT116 cells, which all lack p53 expression. | Oxaliplatin | tumor protein p53 | Homo sapiens |
| 4 | In the present study, oxaliplatin was found to strongly inhibit the growth of HCT116 cells harboring wild-type p53 but to only weakly inhibit SW480 cells, HT29 cells or p53-/- HCT116 cells, which all lack p53 expression. | Oxaliplatin | tumor protein p53 | Homo sapiens |
| 5 | Administration of oxaliplatin significantly induced p53 accumulation and enhanced expression of CYP2S1 in HCT116 cells with wild-type p53. | Oxaliplatin | tumor protein p53 | Homo sapiens |
| 6 | Administration of oxaliplatin significantly induced p53 accumulation and enhanced expression of CYP2S1 in HCT116 cells with wild-type p53. | Oxaliplatin | tumor protein p53 | Homo sapiens |
| 7 | Interestingly, enzyme immunoassays, TOPFlash/FOPFlash reporter activity assays and western blotting analysis demonstrated oxaliplatin-mediated downregulation of PGE2 and Wnt/beta-catenin signaling in a manner dependent on p53. | Oxaliplatin | tumor protein p53 | Homo sapiens |
| 8 | These results suggest that oxaliplatin exerts its inhibitory effects in human CRC cells via upregulation of CYP2S1 expression in a p53-dependent manner. | Oxaliplatin | tumor protein p53 | Homo sapiens |