Pub. Date : 2019 Apr 2
PMID : 30987009
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Intriguingly, 25 muM luteolin reduced cell viability through apoptotic induction, which was intensified in p53-expressing cells while 1 muM oxaliplatin caused cell cycle arrest at G0/G1-phase via the p53/p21-dependent mechanism. | Oxaliplatin | tumor protein p53 | Homo sapiens |
| 2 | Moreover, luteolin treatment was found to reduce oxaliplatin-treated p53-null cell viability and colony counts further, thereby demonstrating an additional effect of luteolin in the killing of human colorectal tumor HCT116 cells not expressing functional p53 protein. | Oxaliplatin | tumor protein p53 | Homo sapiens |
| 3 | The findings suggest that luteolin can induce p53-mediated apoptosis regardless of oxaliplatin treatment and may eliminate oxaliplatin-resistant p53-null colorectal cells. | Oxaliplatin | tumor protein p53 | Homo sapiens |