Title : Metformin accelerates wound healing by Akt phosphorylation of gingival fibroblasts in insulin-resistant prediabetes mice.

Pub. Date : 2022 Feb

PMID : 34427916






3 Functional Relationships(s)
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1 Metformin accelerate wound healing by Akt phosphorylation of gingival fibroblast in insulin-resistant prediabetes mice. Metformin thymoma viral proto-oncogene 1 Mus musculus
2 Metformin treatment significantly recovered the downregulated Akt phosphorylation and VEGF expression in high-glucose conditions. Metformin thymoma viral proto-oncogene 1 Mus musculus
3 CONCLUSIONS: Metformin improved delayed gingival wound healing in insulin-resistant prediabetes by accelerating HGFs proliferation and migration via Akt phosphorylation in insulin signaling pathway. Metformin thymoma viral proto-oncogene 1 Mus musculus