Pub. Date : 2020 Jul-Aug
PMID : 33099954
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin induces apoptosis of melanoma B16 cells via PI3K/Akt/mTOR signaling pathways. | Metformin | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | PURPOSE: To investigate the influences of metformin on the proliferation and apoptosis of mouse melanoma B16 cells through regulating the phosphatidylinositol 3-hydroxy kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathway. | Metformin | thymoma viral proto-oncogene 1 | Mus musculus |
| 3 | CONCLUSIONS: Metformin can inhibit the proliferation of mouse melanoma B16 cells and induce their apoptosis probably through its regulation on the PI3K/AKT/mTOR signaling pathway in cells. | Metformin | thymoma viral proto-oncogene 1 | Mus musculus |