Title : AMP-activated protein kinase inhibits IGF-I signaling and protein synthesis in vascular smooth muscle cells via stimulation of insulin receptor substrate 1 S794 and tuberous sclerosis 2 S1345 phosphorylation.

Pub. Date : 2010 Jun

PMID : 20363874






1 Functional Relationships(s)
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1 These findings are relevant to whole animal physiology because administration of metformin to mice resulted in inhibition of IGF-I-stimulated phosphorylation of Akt/mTOR/p70S6K. Metformin thymoma viral proto-oncogene 1 Mus musculus