Title : Metformin improves endothelial function in aortic tissue and microvascular endothelial cells subjected to diabetic hyperglycaemic conditions.

Pub. Date : 2015 Dec 1

PMID : 26467186






2 Functional Relationships(s)
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1 The 3-h exposure of MMECs to metformin significantly (P<0.05) reversed the HG-induced reduction in phosphorylation of both eNOS and Akt; however, no changes were detected for phosphorylation of AMPK or the expression of SIRT1. Metformin thymoma viral proto-oncogene 1 Mus musculus
2 Our data indicate that a 3-h exposure to metformin can reverse/reduce the impact of HG on endothelial function, via mechanisms linked to increased phosphorylation of eNOS and Akt. Metformin thymoma viral proto-oncogene 1 Mus musculus