Tyrosine

signal transducer and activator of transcription 5B ; Homo sapiens







57 Article(s)
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1 33248444 A Case of Luscan-Lumish Syndrome: Possible Involvement of Enhanced GH Signaling. 2021 Mar 8 2
2 30835430 The STAT5b Linker Domain Mediates the Selectivity of Catechol Bisphosphates for STAT5b over STAT5a. 2019 Apr 19 1
3 31861239 A Novel Inhibitor of STAT5 Signaling Overcomes Chemotherapy Resistance in Myeloid Leukemia Cells. 2019 Dec 17 1
4 29844444 Dominant-negative STAT5B mutations cause growth hormone insensitivity with short stature and mild immune dysregulation. 2018 May 29 1
5 28400581 Rational development of Stafib-2: a selective, nanomolar inhibitor of the transcription factor STAT5b. 2017 Apr 11 1
6 27035235 Suppression of STAT5b in pancreatic cancer cells leads to attenuated gemcitabine chemoresistance, adhesion and invasion. 2016 Jun 1
7 23160480 Severe growth deficiency is associated with STAT5b mutations that disrupt protein folding and activity. 2013 Jan 2
8 22442148 Signal transducer and activator of transcription 5b (Stat5b) serine 193 is a novel cytokine-induced phospho-regulatory site that is constitutively activated in primary hematopoietic malignancies. 2012 May 11 1
9 20962506 A novel Y332C missense mutation in the intracellular domain of the human growth hormone receptor does not alter STAT5b signaling: redundancy of GHR intracellular tyrosines involved in STAT5b signaling. 2011 6
10 20433855 Multi-component signaling complexes of the delta-opioid receptor with STAT5B and G proteins. 2010 Sep 1
11 21166888 Novel functional hepatocyte cell line derived from spontaneous dwarf rat: model of growth hormone function in vitro. 2010 Nov 1
12 19349617 The 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis requires Janus kinase 2-signal transducer and activator of transcription-5B-dependent expression of interleukin-8. 2009 Jun 4 1
13 19438593 c-Src tyrosine kinase co-associates with and phosphorylates signal transducer and activator of transcription 5b which mediates the proliferation of normal human B lymphocytes. 2009 Jun 3
14 18430728 Box 2 region of the oncostatin M receptor determines specificity for recruitment of Janus kinases and STAT5 activation. 2008 Jul 11 2
15 18550772 Signal transducer and activator of transcription 5b, c-Src, and epidermal growth factor receptor signaling play integral roles in estrogen-stimulated proliferation of estrogen receptor-positive breast cancer cells. 2008 Aug 5
16 16862179 Neurotensin stimulates mitogenesis of prostate cancer cells through a novel c-Src/Stat5b pathway. 2007 Feb 1 4
17 17822672 S731 in the transactivation domain modulates STAT5b activity. 2007 Nov 3 1
18 17823285 Suppression of activation of signal transducer and activator of transcription-5B signaling in the vessel wall reduces balloon injury-induced neointima formation. 2007 Oct 1
19 17997837 Signal transducer and activator of transcription 5b: a new target of breast tumor kinase/protein tyrosine kinase 6. 2007 1
20 16303763 Aberrant folding of a mutant Stat5b causes growth hormone insensitivity and proteasomal dysfunction. 2006 Mar 10 1
21 16464942 A mutant signal transducer and activator of transcription 5b, associated with growth hormone insensitivity and insulin-like growth factor-I deficiency, cannot function as a signal transducer or transcription factor. 2006 Apr 2
22 16584384 Signalling cross-talk between hepatocyte nuclear factor 4alpha and growth-hormone-activated STAT5b. 2006 Jul 1 4
23 16772534 Modulation of signal transducer and activator of transcription 5b activity in breast cancer cells by mutation of tyrosines within the transactivation domain. 2006 Oct 2
24 15749807 Prolonged insulin treatment inhibits GH signaling via STAT3 and STAT1. 2005 Mar 1
25 15795318 {beta}1 Integrin and IL-3R coordinately regulate STAT5 activation and anchorage-dependent proliferation. 2005 Mar 28 1
26 15831712 Interleukin-1 inhibits the induction of insulin-like growth factor-I by growth hormone in CWSV-1 hepatocytes. 2005 Aug 1
27 15976008 Estrogen negatively regulates epidermal growth factor (EGF)-mediated signal transducer and activator of transcription 5 signaling in human EGF family receptor-overexpressing breast cancer cells. 2005 Nov 1
28 16155412 Hypoxia activates the cyclin D1 promoter via the Jak2/STAT5b pathway in breast cancer cells. 2005 Aug 31 1
29 14730712 Signaling through JAK2-STAT5 pathway is essential for IL-3-induced activation of microglia. 2004 Jan 15 1
30 15121872 Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta. 2004 May 1
31 12429742 STAT5b, a Mediator of Synergism between c-Src and the Epidermal Growth Factor Receptor. 2003 Jan 17 13
32 12621061 Signal transduction pathways regulated by prolactin and Src result in different conformations of activated Stat5b. 2003 May 9 4
33 11751923 Novel activation of STAT5b in response to epidermal growth factor. 2002 Mar 8 2
34 11781254 Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin. 2002 Jan 15 1
35 12089361 Synergistic action of prolactin (PRL) and androgen on PRL-inducible protein gene expression in human breast cancer cells: a unique model for functional cooperation between signal transducer and activator of transcription-5 and androgen receptor. 2002 Jul 2
36 11448122 Leptin receptor long-form signalling in a human liver cell line. 2001 May 21 1
37 11562369 Inhibitory cross-talk between STAT5b and liver nuclear factor HNF3beta: impact on the regulation of growth hormone pulse-stimulated, male-specific liver cytochrome P-450 gene expression. 2001 Nov 16 2
38 11577084 The Stat1 binding motif of the interferon-gamma receptor is sufficient to mediate Stat5 activation and its repression by SOCS3. 2001 Dec 7 1
39 11731617 Serine phosphorylation of GH-activated signal transducer and activator of transcription 5a (STAT5a) and STAT5b: impact on STAT5 transcriptional activity. 2001 Dec 4
40 10830280 Stat 5B, activated by insulin in a Jak-independent fashion, plays a role in glucokinase gene transcription. 2000 Jun 1
41 10847629 Interleukin-6 signal transduction in human intestinal epithelial cells. 2000 Jun 1
42 10068671 Interferon-alpha activates multiple STAT proteins and upregulates proliferation-associated IL-2Ralpha, c-myc, and pim-1 genes in human T cells. 1999 Mar 15 1
43 10205146 Thrombopoietin stimulates endothelial cell motility and neoangiogenesis by a platelet-activating factor-dependent mechanism. 1999 Apr 16 3
44 10350046 MEK is a negative regulator of Stat5b in PDGF-stimulated cells. 1999 Apr 30 1
45 10373548 SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation. 1999 Jul 1
46 10585430 SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms. 1999 Dec 10 3
47 10618497 Insulin selectively activates STAT5b, but not STAT5a, via a JAK2-independent signalling pathway in Kym-1 rhabdomyosarcoma cells. 1999 Dec 31 2
48 9422769 Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils. Selective activation of Jak2, Stat3, and Stat5b. 1998 Jan 9 1
49 9544991 Dominant negative variants of the SHP-2 tyrosine phosphatase inhibit prolactin activation of Jak2 (janus kinase 2) and induction of Stat5 (signal transducer and activator of transcription 5)-dependent transcription. 1998 Apr 1
50 9657743 Erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B in primary cultured human erythroid precursors. 1998 Jul 15 2