Title : Estrogen negatively regulates epidermal growth factor (EGF)-mediated signal transducer and activator of transcription 5 signaling in human EGF family receptor-overexpressing breast cancer cells.

Pub. Date : 2005 Nov

PMID : 15976008






1 Functional Relationships(s)
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1 Introduction of ERalpha and treatment with E2 decreased EGF-induced tyrosine phosphorylation of STAT5b, basal and EGF-induced STAT5-mediated transcription, and EGF-stimulated DNA synthesis in these cells. Tyrosine signal transducer and activator of transcription 5B Homo sapiens