Title : A mutant signal transducer and activator of transcription 5b, associated with growth hormone insensitivity and insulin-like growth factor-I deficiency, cannot function as a signal transducer or transcription factor.

Pub. Date : 2006 Apr

PMID : 16464942






2 Functional Relationships(s)
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1 However, the Src family of nonreceptor kinases [constitutively active v-src and epithelial growth factor-induced c-src] tyrosine-phosphorylated STAT5b(A630P). Tyrosine signal transducer and activator of transcription 5B Homo sapiens
2 CONCLUSIONS: The A630P mutation disrupts the src-homology-2 architecture such that: 1) mutant STAT5b most likely cannot dock to phospho-tyrosines on ligand-activated receptors; and 2) stable interactions with DNA are prevented. Tyrosine signal transducer and activator of transcription 5B Homo sapiens