Title : Dominant negative variants of the SHP-2 tyrosine phosphatase inhibit prolactin activation of Jak2 (janus kinase 2) and induction of Stat5 (signal transducer and activator of transcription 5)-dependent transcription.

Pub. Date : 1998 Apr

PMID : 9544991






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The dominant negative mutant of SHP-2 was found to inhibit the induction of tyrosine phosphorylation and DNA-binding activity of m-Stat5a, m-Stat5b, and the carboxyl-terminal deletion variant m-Stat5adelta749, as well as the transactivation potential of m-Stat5a and m-Stat5b. Tyrosine signal transducer and activator of transcription 5B Homo sapiens