Title : Signal transducer and activator of transcription 5b, c-Src, and epidermal growth factor receptor signaling play integral roles in estrogen-stimulated proliferation of estrogen receptor-positive breast cancer cells.

Pub. Date : 2008 Aug

PMID : 18550772






5 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 E2 treatment stimulated STAT5b tyrosine phosphorylation at the activating tyrosine Y699, resulting in increased STAT5-mediated transcriptional activity, which was inhibited by a Y669F STAT5b mutant. Tyrosine signal transducer and activator of transcription 5B Homo sapiens
2 E2 treatment stimulated STAT5b tyrosine phosphorylation at the activating tyrosine Y699, resulting in increased STAT5-mediated transcriptional activity, which was inhibited by a Y669F STAT5b mutant. Tyrosine signal transducer and activator of transcription 5B Homo sapiens
3 E2 treatment stimulated STAT5b tyrosine phosphorylation at the activating tyrosine Y699, resulting in increased STAT5-mediated transcriptional activity, which was inhibited by a Y669F STAT5b mutant. Tyrosine signal transducer and activator of transcription 5B Homo sapiens
4 E2 treatment stimulated STAT5b tyrosine phosphorylation at the activating tyrosine Y699, resulting in increased STAT5-mediated transcriptional activity, which was inhibited by a Y669F STAT5b mutant. Tyrosine signal transducer and activator of transcription 5B Homo sapiens
5 Both E2-induced STAT5b tyrosine phosphorylation and STAT5-mediated transcription were also inhibited by the ER antagonist ICI 182,780 and the c-Src inhibitor PP2, indicating additional requirements for the ER and c-Src kinase activity. Tyrosine signal transducer and activator of transcription 5B Homo sapiens