Title : Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta.

Pub. Date : 2004 May

PMID : 15121872






1 Functional Relationships(s)
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1 We show that phosphorylation of tyrosine 813 is required for the SH2 domain-containing adapter protein SH2-B beta to bind JAK2 and to enhance the activity of JAK2 and STAT5B. Tyrosine signal transducer and activator of transcription 5B Homo sapiens